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Colorimetric pH-responsive and hemostatic hydrogel-based bioadhesives containing functionalized silver nanoparticles
Elham Khadem1, Mahshid Kharaziha1,2, Sahar Salehi2
1Department of Materials Engineering, Isfahan University of Technology, 84156-83111, Isfahan, Iran.
Materials Today. Bio
|May 19, 2023
Summary
This study presents a new dual-cross-linked pH-responsive hydrogel (carboxyethyl chitosan-oxidized sodium alginate with silver nanoparticles) that enhances wound healing. The developed hydrogel offers improved strength, antibacterial action, and hemostatic properties for smart bioadhesives.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Nanotechnology
Background:
- Hydrogels are crucial in biomedical applications, but limitations exist in their mechanical strength, responsiveness, and antimicrobial activity.
- Developing advanced hydrogels with enhanced properties is essential for effective wound management and tissue engineering.
Purpose of the Study:
- To develop and characterize a novel dual-cross-linked, pH-responsive hydrogel incorporating silver nanoparticles functionalized with tannic acid/red cabbage.
- To evaluate the hydrogel's mechanical properties, pH sensitivity, hemostatic ability, antibacterial efficacy, and cytocompatibility for wound bioadhesive applications.
Main Methods:
- Fabrication of a hybrid hydrogel using covalent and non-covalent cross-linking of carboxyethyl chitosan-oxidized sodium alginate (CAO) with tannic acid/red cabbage-functionalized silver nanoparticles (ATR).
- Assessment of adhesive and compression strength, cyclic compression tests for elastic behavior, pH-sensitivity testing via color change, hemostatic property evaluation, antibacterial assays against Gram-positive and Gram-negative bacteria, and L929 fibroblast cytocompatibility tests.
Main Results:
- The CAO/ATR hydrogel exhibited significantly enhanced adhesive and compression strength (over 3 times higher than CAO).
- Incorporation of ATR-functionalized nanoparticles improved elastic behavior and compression strength from 35.1 ± 2.1 kPa to 97.5 ± 2.9 kPa.
- The CAO/ATR hydrogel demonstrated pH sensitivity with visible color changes, improved hemostatic properties (reduced clotting time), broad-spectrum antibacterial activity, and cytocompatibility.
Conclusions:
- The developed CAO/ATR hydrogel shows significant promise as a smart wound bioadhesive.
- Its enhanced mechanical properties, pH responsiveness, antibacterial efficacy, and hemostatic capabilities make it suitable for advanced wound care applications.
- The hydrogel's cytocompatibility further supports its potential for biomedical use.
