Related Experiment Video
Updated: Jul 29, 2025

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology
Published on: March 24, 2015
Revolutionizing Cancer Treatment: Harnessing the Power of Biomarkers to Improve Patient Outcomes
Donald C Moore1, Andrew S Guinigundo2
1From Department of Pharmacy, Levine Cancer Institute, Atrium Health, Charlotte, North Carolina.
Abstract:
There has been an increasing number of approvals for targeted therapies and immunotherapies in oncology in the past decade. This has changed the treatment paradigm for many solid tumors and hematologic malignancies, and therefore the outcomes of patients with cancer. Advanced practitioners should be up to date with advances in cancer biomarker testing and its implications for the use of targeted therapy and immunotherapy to integrate this information into clinical decision-making.
Insights
The number of targeted and immunotherapy cancer treatments has grown, improving patient outcomes. Advanced practitioners must stay updated on biomarker testing for effective clinical decision-making.
Area of Science:
- Oncology
- Molecular Biology
- Clinical Medicine
Background:
- The last decade has seen a significant rise in targeted therapy and immunotherapy approvals in oncology.
- These novel treatments have fundamentally altered the management and prognosis of numerous solid tumors and hematologic malignancies.
Purpose of the Study:
- To highlight the importance of staying current with advancements in cancer biomarker testing.
- To emphasize the implications of these tests for utilizing targeted therapy and immunotherapy.
- To guide advanced practitioners in integrating biomarker information into clinical decision-making.
Main Methods:
- This abstract is based on a review of recent trends in oncology treatment approvals and clinical practice guidelines.
- It synthesizes information regarding the impact of biomarker testing on therapeutic strategies.
Main Results:
- Increased approvals for targeted therapies and immunotherapies have led to improved patient outcomes.
- Biomarker testing is crucial for identifying patients who will benefit from these specific treatments.
Conclusions:
- Advanced practitioners need to maintain up-to-date knowledge of cancer biomarker testing.
- Integrating biomarker data into clinical decisions is essential for optimizing the use of targeted therapy and immunotherapy.
- Continuous education is vital for leveraging these advancements in cancer care.
More Related Videos
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Tumor Immunotherapy
Cancer Survival Analysis
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

