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The effect of taurine on flap perfusion and viability in random pattern flaps in rats
Mert Ersan1, Burak Kaya1, Arda Özdemir1
1Ankara University Faculty of Medicine, Plastic Reconstructive and Aesthetic Surgery Department, Ankara.
Background:
In present study, the effect of taurine on flap perfusion and viability was examined using the modified random pattern dorsal flap model (DFM).
Materials And Methods:
Eighteen rats were included and divided equally (n=9) to taurine treatment and control groups in this study. Taurine treatments were given orally at a dose of 100 mg/kg/day. Taurine group received taurine, starting 3 days before the operation till the postoperative 3rd day. Angiographic images were recorded when the flaps were sutured back and on postoperative 5th and 7th days. Necrosis calculations were made with all the images obtained by the digital camera and the indocyanine green angiography. Fluorescence intensity, fluorescence filling rate and flow rate of DFM were calculated by the SPY device and the SPY-Q software. All flaps were analyzed histopathologically, also.
Results:
Perioperative taurine treatment significantly reduced necrosis rates and increased the fluorescence density, the fluorescence filling rate and the flap filling rates in the DFM (p<0.05). Reduced amounts of necrosis, ulcer and polymorphonuclear leukocyte supported the beneficial effect of taurine histopathologically (p<0.05).
Conclusions:
Taurine may be used as an effective medical agent for prophylactic treatment options in flap surgery.
