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Updated: Aug 15, 2026

In Vitro Assay to Measure Phosphatidylethanolamine Methyltransferase Activity
Published on: January 5, 2016
S-adenosyl-L-methionine modulates phosphatidylethanolamine methyltransferase response to isoproterenol in brain
Abstract:
The effect of l-isoproterenol on S-adenosyl-L-methionine (Adomet)-mediated phospholipid methylation in rat brain cortex was examined. Under conditions which favor the activity of methyltransferase I (i.e. low Adomet), formation of phosphatidyl-N-methylethanolamine was inhibited by l-isoproterenol. On the other hand, methyltransferase II activity (i.e. high Adomet) was stimulated by l-isoproterenol. The results suggest that Adomet may play a regulatory role in the response of phospholipid methyltransferases to catecholamines in brain.
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