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Light-Controlled Fermentations for Microbial Chemical and Protein Production
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Microbial production of mevalonate
Cong-Han Wang1, Jie Hou1, Hong-Kuan Deng1
1School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China.
Journal of Biotechnology
|May 20, 2023
Summary
Microbial biosynthesis of mevalonate, a key metabolic intermediate, is promising for industrial applications. This review covers mevalonate applications, biosynthesis pathways, and metabolic engineering strategies for enhanced production in microorganisms.
Area of Science:
- Biochemistry
- Metabolic Engineering
- Synthetic Biology
Background:
- Mevalonate is a crucial intermediate in the mevalonate pathway with diverse applications.
- Advances in metabolic engineering and synthetic biology enable microbial mevalonate biosynthesis.
- Microbial production offers a promising sustainable route for mevalonate supply.
Purpose of the Study:
- To review the applications of mevalonate and its derivatives.
- To describe mevalonate biosynthesis pathways.
- To detail current mevalonate biosynthesis status and metabolic engineering strategies.
Main Methods:
- Literature review of mevalonate applications and biosynthesis.
- Analysis of metabolic engineering strategies for enhancing production.
- Focus on industrial microorganisms like Escherichia coli, Saccharomyces cerevisiae, and Pseudomonas putida.
Main Results:
- Mevalonate has broad applications, driving interest in its biosynthesis.
- Microbial biosynthesis pathways are well-established.
- Metabolic engineering offers significant potential for improving mevalonate yields.
Conclusions:
- Microbial mevalonate biosynthesis is a feasible and promising technology.
- Metabolic engineering strategies are key to efficient industrial production.
- Further research can optimize biosynthesized mevalonate for various applications.
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