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Related Experiment Video

Updated: Jul 29, 2025

Oral Biofilm Analysis of Palatal Expanders by Fluorescence In-Situ Hybridization and Confocal Laser Scanning Microscopy
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What Is the Microbial Profile in Persistent Endodontic Infections? A Scoping Review.

K P Pinto1, A F A Barbosa1, E J N L Silva2

  • 1Department of Endodontics, School of Dentistry, State University of Rio de Janeiro (UERJ), Rio de Janeiro, Rio de Janeiro, Brazil.

Journal of Endodontics
|May 21, 2023
PubMed
Summary
This summary is machine-generated.

Persistent endodontic infections involve multiple bacteria, with Enterococcus faecalis being common. Inadequate root canal fillings and restorations correlate with increased microbial presence and specific species.

Keywords:
Endodonticsmicroorganismspersistent intraradicular infectionscoping review

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Area of Science:

  • Endodontology
  • Microbiology
  • Infectious Diseases

Background:

  • Persistent endodontic infections represent a significant clinical challenge.
  • Understanding the microbial landscape is crucial for effective treatment strategies.

Purpose of the Study:

  • To systematically map the existing evidence on the microbiota associated with persistent endodontic infections.
  • To identify prevalent microbial species and factors influencing their presence.

Main Methods:

  • A comprehensive scoping review was conducted.
  • Searches were performed across multiple major scientific databases.
  • Eligibility criteria focused on clinical studies evaluating microbial profiles in teeth undergoing endodontic retreatment.

Main Results:

  • 32 studies were included, identifying a polymicrobial profile.
  • Key species include Enterococcus faecalis, Parvimonas micra, and Porphyromonas species.
  • Symptomatology, inadequate root canal filling, and poor coronal restoration were linked to increased microbial load and specific species.

Conclusions:

  • Persistent endodontic infections are characterized by a polymicrobial community.
  • Current detection methods have inherent limitations.
  • Clinical factors like restoration quality significantly impact the endodontic microbiome.