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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

334
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
334
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

414
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
414
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

654
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
654
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

529
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
529
Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

239
Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
239
Routes of Drug Administration: Parenteral01:25

Routes of Drug Administration: Parenteral

2.0K
The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
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In Vitro Imaging and Quantification of the Drug Targeting Efficiency of Fluorescently Labeled GnRH Analogues
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Octreotide and Octreotide-derived delivery systems.

Mingliang Fan1, Yue Huang1, Xinlin Zhu2

  • 1School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.

Journal of Drug Targeting
|May 22, 2023
PubMed
Summary
This summary is machine-generated.

Octreotide, a somatostatin analog, shows promise in targeted cancer therapies and diagnostics. This review highlights Octreotide-derived delivery systems for preclinical tumor targeting, therapeutics, and diagnostics.

Keywords:
Octreotidecancer therapydiagnostic nanosystemsdrug deliverytherapeutic nanosystemstumour targeting

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Area of Science:

  • Pharmaceutical Science
  • Oncology
  • Nanotechnology

Background:

  • Octreotide is a somatostatin analog approved for treating acromegaly and neuroendocrine tumors.
  • Octreotide-based radioactive conjugates are used clinically for detecting neuroendocrine tumor sites.
  • Various Octreotide-derived delivery strategies have been explored for targeted therapeutics and diagnostics.

Purpose of the Study:

  • To review the preclinical development and applications of Octreotide-derived drug delivery systems.
  • To focus on diagnostic, therapeutic, and multifunctional nanosystems derived from Octreotide.
  • To discuss the challenges and future prospects of these Octreotide-derived delivery systems.

Main Methods:

  • Literature review focusing on preclinical studies.
  • Analysis of Octreotide-derived drug delivery systems, diagnostic nanosystems, therapeutic nanosystems, and multifunctional nanosystems.
  • Discussion of challenges and prospects in the field.

Main Results:

  • Octreotide-derived systems show potential for targeted drug delivery in preclinical settings.
  • Diagnostic and therapeutic nanosystems based on Octreotide are being developed.
  • Multifunctional nanosystems offer combined diagnostic and therapeutic capabilities.

Conclusions:

  • Octreotide-derived delivery systems represent a promising area for preclinical cancer research.
  • Further development is needed to address challenges and realize the full potential of these systems.
  • These systems offer a versatile platform for advancing Octreotide-based cancer diagnostics and therapeutics.