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Octreotide and Octreotide-derived delivery systems

Mingliang Fan1, Yue Huang1, Xinlin Zhu2

  • 1School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.

Journal of Drug Targeting
|May 22, 2023
PubMed

Insights

Octreotide, a somatostatin analog, shows promise in targeted cancer therapies and diagnostics. This review highlights Octreotide-derived delivery systems for preclinical tumor targeting, therapeutics, and diagnostics.

Area of Science:

  • Pharmaceutical Science
  • Oncology
  • Nanotechnology

Background:

  • Octreotide is a somatostatin analog approved for treating acromegaly and neuroendocrine tumors.
  • Octreotide-based radioactive conjugates are used clinically for detecting neuroendocrine tumor sites.
  • Various Octreotide-derived delivery strategies have been explored for targeted therapeutics and diagnostics.

Purpose of the Study:

  • To review the preclinical development and applications of Octreotide-derived drug delivery systems.
  • To focus on diagnostic, therapeutic, and multifunctional nanosystems derived from Octreotide.
  • To discuss the challenges and future prospects of these Octreotide-derived delivery systems.

Main Methods:

  • Literature review focusing on preclinical studies.
  • Analysis of Octreotide-derived drug delivery systems, diagnostic nanosystems, therapeutic nanosystems, and multifunctional nanosystems.
  • Discussion of challenges and prospects in the field.

Main Results:

  • Octreotide-derived systems show potential for targeted drug delivery in preclinical settings.
  • Diagnostic and therapeutic nanosystems based on Octreotide are being developed.
  • Multifunctional nanosystems offer combined diagnostic and therapeutic capabilities.

Conclusions:

  • Octreotide-derived delivery systems represent a promising area for preclinical cancer research.
  • Further development is needed to address challenges and realize the full potential of these systems.
  • These systems offer a versatile platform for advancing Octreotide-based cancer diagnostics and therapeutics.
Keywords:
Octreotidecancer therapydiagnostic nanosystemsdrug deliverytherapeutic nanosystemstumour targeting

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