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Related Experiment Video

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Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks

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Tunable Organic Active Neural Probe Enabling Near-Sensor Signal Processing.

Yongwoo Lee¹, Alejandro Carnicer-Lombarte², Sanggil Han^2,3

¹Department of Convergence IT Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk, 37673, Republic of Korea.

Advanced Materials (Deerfield Beach, Fla.)

|May 22, 2023

Summary

This summary is machine-generated.

Researchers developed inkjet-printed organic voltage amplifiers for flexible neural probes. This innovation reduces noise and enables near-sensor signal processing for improved in vivo brain activity recording.

Keywords:

active neural probes in vivo recordings inkjet-printings organic electrochemical transistors voltage amplifiers

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Area of Science:

Neuroscience
Materials Science
Biomedical Engineering

Background:

Advanced neural recording systems are crucial for understanding and treating neurological disorders.
Flexible transistor-based active neural probes offer advantages in electrophysiology due to amplification and tissue compatibility.
Current limitations include bulky connectivity and the need for integrated voltage output for near-sensor processing.

Purpose of the Study:

To develop an integrated circuit for voltage output in active neural probes.
To create a flexible, inkjet-printed organic voltage amplifier for in vivo brain activity recording.
To improve signal processing at the abiotic/biotic interface for neural probes.

Main Methods:

Monolithic integration of organic electrochemical transistors and thin-film polymer resistors on a flexible substrate using inkjet printing.
Development of organic voltage amplifiers for seamless integration on the somatosensory cortex.
Validation of devices as electrocorticography (ECoG) tools in a rat in vivo model.

Main Results:

Additive inkjet printing enabled seamless integration of active and passive components.
Significant noise reduction was achieved compared to externally connected configurations.
Fine-tuning of voltage amplification and frequency properties was facilitated.
Successful recording of local field potentials in a rat model of spontaneous and epileptiform activity.

Conclusions:

Inkjet-printed organic voltage amplifiers represent a significant advancement for active neural probes.
These amplifiers facilitate efficient sensory data processing at sensor endpoints.
The technology holds promise for improved in vivo brain activity recording and neurological disease treatment.