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Updated: Jul 29, 2025

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI
Published on: November 22, 2016
Zn-Mediated Scalable Synthesis of Trifluoromethylphosphines from Phosphine Chlorides and CF3Br
Deqian Peng1,2, Shouzhi Zhang1, Wu Fan3
1School of Chemistry, Sun Yat-Sen University, Guangzhou, Guangdong 510006, P. R. China.
Abstract:
Trifluoromethylphosphines represent a rare kind of phosphine with unique electronic withdrawing properties, which lead to some distinctive reactivities. The reported TFMPhos, products from nucleophilic or electrophilic trifluoromethylation of substrates, requiring one or more steps and prepared from phosphine chlorides, are very limited in structure diversity. Herein, we report a convenient and scalable (up to 100 mmol) recipe to synthesize diverse trifluoromethylphosphines via direct radical trifluoromethylation of phosphine chlorides with CF3Br in the presence of zinc powder.
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