Related Experiment Video
Updated: Jul 29, 2025
09:08
Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
Published on: January 12, 2020
6.8K
Comprehensive Analysis Identifies the PPAR-Targeted Genes Associated with Ovarian Cancer Prognosis and Tumor
Xiao-Fei Leng1, Gao-Fa Wang1, Hao Yin1
1Department of Obstetrics and Gynecology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
PPAR Research
|May 22, 2023
Summary
This study reveals a new prognostic signature for ovarian cancer (OC) using peroxisome proliferator-activated receptors (PPARs) target genes. This signature aids in predicting patient survival and guides future research on PPARs in OC.
Area of Science:
- Oncology
- Molecular Biology
- Genomics
Background:
- Peroxisome proliferator-activated receptors (PPARs) are implicated in cancer development.
- The specific role of PPARs-related genes in ovarian cancer (OC) is not well understood.
Purpose of the Study:
- To comprehensively investigate PPAR target genes in OC.
- To establish a prognostic signature for OC patients based on PPAR target genes.
- To explore the biological roles and clinical implications of these genes in OC.
Main Methods:
- Analysis of open-accessed data from The Cancer Genome Atlas (TCGA).
- Utilized R software for comprehensive data analysis.
- Developed a prognostic signature using eight PPAR target genes.
- Constructed a nomogram integrating clinical features and risk scores.
- Performed immune infiltration, biological enrichment, immunotherapy, and drug sensitivity analyses.
Main Results:
- A prognostic signature comprising eight PPAR target genes (including ECH1) was established with good prediction efficiency for OC patient survival.
- Differences in immune infiltration and biological pathways were observed between high- and low-risk patient groups.
- Low-risk patients may benefit more from immunotherapy.
- Specific drug sensitivities were identified for high-risk patients, including responses to bleomycin, nilotinib, pazopanib, pyrimethamine, and vinorelbine, with resistance to cisplatin and gefitinib.
Conclusions:
- The identified prognostic signature effectively indicates patient survival in OC.
- This study provides a foundation for future research into the role of PPARs in ovarian cancer.
- The gene ECH1 was highlighted for further investigation.
Related Concept Videos
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
7.6K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.6K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
02:07Tumor Progression
6.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K