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Related Concept Videos

Induced Electric Fields: Applications01:27

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An important distinction exists between the electric field induced by a changing magnetic field and the electrostatic field produced by a fixed charge distribution. Specifically, the induced electric field is nonconservative because it does not work in moving a charge over a closed path. In contrast, the electrostatic field is conservative and does no net work over a closed path. Hence, electric potential can be associated with the electrostatic field but not the induced field. The following...
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Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
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The fact that emfs are induced in circuits implies that work is being done on the conduction electrons in the wires. What can possibly be the source of this work? We know that it’s neither a battery nor a magnetic field, as a battery does not have to be present in a circuit where current is induced, and magnetic fields never do any work on moving charges. The source of the work is in fact an electric field that is induced in the wires. For example, if a stationary conductor is placed in a...
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Monitoring Electroporation-Induced Changes in Action Potential Generation in Genetically Engineered Tet-On Spiking HEK cells
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Electrically stimulated gene expression under exogenously applied electric fields.

Sara Abasi1, Abhishek Jain1,2,3, John P Cooke2

  • 1Bioelectronics, Biosensors and Biochips (C3B), Department of Biomedical Engineering, Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, United States.

Frontiers in Molecular Biosciences
|May 22, 2023
PubMed
Summary
This summary is machine-generated.

Electrical stimulation influences human endothelial cell gene expression, with frequency being more significant than voltage. This finding has implications for cardiovascular tissue engineering and regenerative medicine.

Keywords:
CD-144ECSARAHUVECTEERYAPelectromics

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Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Electrophysiology

Background:

  • Electrical stimulation accelerates cell growth and tight junction formation.
  • Applications include cardiovascular tissue engineering, allotransplantation, and wound healing.

Purpose of the Study:

  • To explore the effects of electric field magnitude and frequency on human endothelial cells (HUVECs).
  • To investigate impacts on cell growth, proliferation, transendothelial electrical resistance (TEER), and gene expression.

Main Methods:

  • Utilized the Electrical Cell Stimulation And Recording Apparatus (ECSARA).
  • Applied electric fields of varying magnitudes and frequencies to HUVECs.
  • Measured TEER and analyzed gene expression, including YAP and CD-144 localization.

Main Results:

  • Electrical stimulation frequency significantly influenced HUVEC gene expression (p=0.05).
  • Voltage magnitude was less significant than frequency.
  • YAP localization and CD-144 expression correlated with TEER changes.

Conclusions:

  • Introduces "electromics": studying cellular gene expression under exogenous electric fields.
  • Electrobiology and mechanobiology share homologies, suggesting applications in tissue and regenerative engineering.