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Preferences reveal separable valuation systems in prefrontal-limbic circuits.

Frederic M Stoll1, Peter H Rudebeck1

  • 1Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.

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New research reveals two distinct brain systems, not one, guide food preferences and choices. The orbitofrontal cortex (OFC) and ventrolateral prefrontal cortex (vlPFC) separately process flavor and probability, influencing decision-making.

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Amygdalaagranular insulachoicesdecision makingflavorinferior frontal gyrusorbitofrontal cortexoutcomepreferenceprobabilityrewardsatietyvaluationventrolateral prefrontal cortex

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Area of Science:

  • Neuroscience
  • Decision-making science
  • Primate behavior

Background:

  • Individual preferences significantly influence food and fluid choices.
  • Current theories suggest a single integrated valuation system in the orbitofrontal cortex (OFC) drives choice behavior.
  • The OFC is believed to compute the relative subjective value of available options.

Approach:

  • Investigated neural mechanisms of preference-based choice in macaque monkeys.
  • Utilized neurophysiological recordings to identify distinct valuation systems.
  • Differentiated the roles of the OFC and ventrolateral prefrontal cortex (vlPFC) in representing outcome value and probability.

Key Points:

  • Identified two separable valuation systems in the brain: one in the OFC and another in the vlPFC.
  • The OFC preferentially represents outcome flavor, while the vlPFC represents outcome probability.
  • Preferences are integrated separately into flavor and probability representations.
  • The vlPFC, unlike the OFC, separately represented outcome probabilities, with their difference reflecting preference intensity.

Conclusions:

  • Orbitofrontal cortex and ventrolateral prefrontal cortex form at least two distinct valuation systems.
  • These systems work in concert to guide choice behavior, with both being influenced by individual preferences.
  • This finding challenges the notion of a single integrated valuation system in the OFC.