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Versatile magnetic hydrogel soft capsule microrobots for targeted delivery.

Zichen Xu1, Zehao Wu1, Mingzhe Yuan2

  • 1Department of Electromechanical Engineering, Faculty of Science and Technology, University of Macau, Macau, China.

Iscience
|May 22, 2023
PubMed
Summary

We developed novel magnetic hydrogel capsule microrobots for precise cargo delivery inside the human body. These microrobots ensure cargo integrity and enable on-demand release, offering a promising solution for internal medical applications.

Keywords:
Biomedical materialsMagnetic propertyRobotics

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Robotics

Background:

  • Accurate cargo delivery within the human body is essential for effective treatments.
  • Current methods face challenges in maintaining cargo integrity and achieving controlled release during complex internal navigations.

Purpose of the Study:

  • To design and demonstrate a novel magnetic hydrogel soft capsule microrobot system.
  • To achieve on-demand cargo release and microrobot swarm deployment with minimal loss.

Main Methods:

  • Fabrication of magnetic hydrogel membranes using CaCl2 solution, magnetic powders, and sodium alginate.
  • Utilizing low-density rotating magnetic fields for microrobot propulsion.
  • Employing strong gradient magnetic fields for hydrogel shell disintegration and cargo release.
  • Remote control and guidance using ultrasound imaging in simulated digestive system environments (acidic and alkaline).

Main Results:

  • Successful creation of magnetic hydrogel capsule microrobots capable of enclosing diverse cargoes and microrobot swarms.
  • Demonstrated physical disintegration of the hydrogel shell for on-demand release with near-zero cargo loss.
  • Effective remote control and navigation of microrobots in simulated gastrointestinal environments.

Conclusions:

  • The proposed magnetic hydrogel capsule microrobots offer a robust platform for targeted internal cargo delivery.
  • This technology shows significant potential for advancing minimally invasive medical treatments and diagnostics.