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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Steady decrease in systemic sclerosis mortality rates at younger ages over the past five decades.

Eric Y Yen1, Devanshu R Singh1,2, Ram Raj Singh1,3,4,5

  • 1Department of Medicine, University of California at Los Angeles (UCLA) David Geffen School of Medicine, Los Angeles, CA, USA.

Rheumatology (Oxford, England)
|May 22, 2023
PubMed
Summary
This summary is machine-generated.

Mortality from Systemic Sclerosis (SSc) has significantly decreased in younger populations over the last 50 years. However, SSc mortality rates have notably increased in older age groups during the same period.

Keywords:
SScageepidemiologylarge databasemortality

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Area of Science:

  • Epidemiology
  • Public Health
  • Rheumatology

Background:

  • Systemic Sclerosis (SSc) is a chronic autoimmune disease with significant mortality implications.
  • Understanding age-specific mortality trends is crucial for public health resource allocation and patient care strategies.
  • Previous research has not comprehensively analyzed SSc mortality trends across all age groups over extended periods.

Purpose of the Study:

  • To evaluate the trends in mortality rates for Systemic Sclerosis (SSc) across different age demographics in the United States general population.
  • To analyze changes in SSc mortality relative to other causes of death over the past five decades (1968-2015).
  • To identify specific age groups experiencing increasing or decreasing SSc mortality.

Main Methods:

  • Population-based study utilizing national mortality and census data for all US residents from 1968 to 2015.
  • Calculation of age-standardized mortality rates (ASMRs) for SSc and non-SSc deaths.
  • Joinpoint regression analysis to determine the average annual percent change (AAPC) in mortality parameters across age groups.

Main Results:

  • For individuals aged 44 years and younger, SSc mortality proportion decreased with an AAPC of -2.2%, and ASMR decreased by 60% (AAPC -1.9%).
  • The ratio of SSc-ASMR to non-SSc-ASMR also decreased by 20% in the younger age group (≤44 years).
  • Conversely, individuals aged 65 years and older experienced a substantial increase in SSc-ASMR (cumulative 187.0%, AAPC 2.0%) and the SSc-ASMR to non-SSc-ASMR ratio (cumulative 395.4%, AAPC 3.3%).

Conclusions:

  • Mortality associated with Systemic Sclerosis (SSc) has shown a consistent decline in younger populations over the last five decades.
  • A significant and concerning rise in SSc mortality has been observed in older populations during the same timeframe.
  • These divergent trends highlight the need for age-specific public health interventions and research into SSc pathogenesis and treatment.