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Updated: Jul 29, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Solving the explainable AI conundrum by bridging clinicians' needs and developers' goals.
Nadine Bienefeld1, Jens Michael Boss2, Rahel Lüthy3
1Department of Management, Technology, and Economics, ETH Zurich, Zürich, Switzerland. n.bienefeld@gmail.com.
Developers and clinicians have differing views on explainable AI (XAI) in healthcare, impacting clinical decision support systems. Addressing these differences is key to effective XAI implementation.
Area of Science:
- Healthcare Informatics
- Artificial Intelligence
- Human-Computer Interaction
Background:
- Explainable artificial intelligence (XAI) is crucial for AI/ML adoption in healthcare.
- Understanding developer and clinician perspectives on XAI is limited.
- Conflicting goals and requirements can hinder XAI implementation.
Purpose of the Study:
- To investigate the differing mental models of developers and clinicians regarding XAI.
- To identify conflicting goals and requirements in XAI co-design for healthcare.
- To propose design solutions for effective XAI in clinical decision support systems.
Main Methods:
- Longitudinal multi-method study.
- Co-design of an XAI solution for a clinical decision support system.
- Involved 112 developers and clinicians.
Main Results:
- Identified three key differences in developer vs. clinician mental models of XAI.
- Differences include opposing goals (interpretability vs. plausibility), sources of truth (data vs. patient), and knowledge exploration vs. exploitation.
- Highlighted the need to reconcile these differing perspectives.
Conclusions:
- Reconciling developer and clinician XAI mental models is vital for healthcare AI.
- Proposed design solutions: causal inference, personalized explanations, and ambidexterity.
- Emphasized considering both stakeholder perspectives for effective XAI in healthcare.
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