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Nano-mediated strategy for targeting and treatment of non-small cell lung cancer (NSCLC)
Sumel Ashique1, Ashish Garg2, Neeraj Mishra3
1Department of Pharmaceutics, Bharat Institute of Technology (BIT), School of Pharmacy, Meerut, 250103, UP, India.
Abstract:
Lung cancer is the most common type of cancer, with over 2.1 million cases diagnosed annually worldwide. It has a high incidence and mortality rate, leading to extensive research into various treatment options, including the use of nanomaterial-based carriers for drug delivery. With regard to cancer treatment, the distinct biological and physico-chemical features of nano-structures have acquired considerable impetus as drug delivery system (DDS) for delivering medication combinations or combining diagnostics and targeted therapy. This review focuses on the use of nanomedicine-based drug delivery systems in the treatment of lung cancer, including the use of lipid, polymer, and carbon-based nanomaterials for traditional therapies such as chemotherapy, radiotherapy, and phototherapy. The review also discusses the potential of stimuli-responsive nanomaterials for drug delivery in lung cancer, and the limitations and opportunities for improving the design of nano-based materials for the treatment of non-small cell lung cancer (NSCLC).
Insights
Nanomedicine offers advanced drug delivery systems for lung cancer treatment. This review explores lipid, polymer, and carbon-based nanomaterials for chemotherapy, radiotherapy, and phototherapy, enhancing non-small cell lung cancer care.
Area of Science:
- Oncology
- Nanotechnology
- Drug Delivery
Background:
- Lung cancer is a leading cause of cancer mortality worldwide, necessitating innovative therapeutic strategies.
- Nanomaterials offer unique properties for targeted drug delivery and combined diagnostic/therapeutic approaches in cancer treatment.
Purpose of the Study:
- To review the application of nanomedicine-based drug delivery systems for lung cancer treatment.
- To explore various nanomaterial types and their use in conventional therapies like chemotherapy, radiotherapy, and phototherapy.
Main Methods:
- Literature review focusing on nanomedicine applications in lung cancer therapy.
- Analysis of lipid, polymer, and carbon-based nanomaterials for drug delivery.
- Discussion of stimuli-responsive nanomaterials and their potential.
Main Results:
- Nanomaterials, including lipid, polymer, and carbon-based types, show promise for enhancing lung cancer treatment efficacy.
- Stimuli-responsive nanomaterials present opportunities for advanced, targeted drug delivery.
- The review identifies limitations and areas for improvement in nano-based material design for non-small cell lung cancer.
Conclusions:
- Nanomedicine-based drug delivery systems are a significant area of research for improving lung cancer treatment outcomes.
- Further development of nanomaterials, particularly stimuli-responsive ones, holds potential for personalized and effective non-small cell lung cancer therapies.
