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Post-operative Tumor Lysis Syndrome in High-Grade Uterine Sarcoma
Hana Qasim1, Himil J Mahadevia2,1, Ben Ponvilawan1
1Internal Medicine, University of Missouri, Kansas City, USA.
Cureus
|May 23, 2023
Summary
Tumor lysis syndrome (TLS) is a rare oncologic emergency, typically seen in blood cancers. This case highlights spontaneous TLS in a solid uterine sarcoma, emphasizing its unusual occurrence and potential risks.
Area of Science:
- Oncology
- Nephrology
- Metabolic Disorders
Background:
- Tumor lysis syndrome (TLS) is a critical oncologic emergency characterized by metabolic disturbances.
- It is commonly associated with hematological malignancies following chemotherapy or radiotherapy.
- Spontaneous TLS in solid tumors, particularly gynecological malignancies, is exceptionally rare.
Observation:
- A 50-year-old female patient developed TLS shortly after surgical resection of high-grade uterine sarcoma.
- This presentation is unusual as TLS typically occurs with treatment initiation, not post-resection.
Findings:
- The case underscores the possibility of spontaneous TLS in solid malignancies, even after tumor removal.
- Review of prior uterine malignancy TLS cases reveals significant associated morbidity and mortality.
Implications:
- This case expands the understanding of TLS occurrence beyond typical triggers and hematological cancers.
- Awareness of spontaneous TLS in uterine sarcoma is crucial for prompt diagnosis and management to mitigate severe complications.
