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Related Concept Videos

Aging01:26

Aging

92
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Mitochondria01:37

Mitochondria

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
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Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

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Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
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Related Experiment Video

Updated: Jul 29, 2025

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
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A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

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Ferulic Acid: Signaling Pathways in Aging.

Deepa Neopane1, Vaseem Ahamad Ansari1, Aditya Singh1

  • 1Department of Pharmacy, Integral University, Lucknow, India.

Drug Research
|May 23, 2023
PubMed
Summary

Ferulic acid protects skin by scavenging free radicals and inhibiting damaging pathways. This antioxidant may offer clinical remedies for age-related skin decline.

Area of Science:

  • Dermatology and Aging Research
  • Biochemistry and Molecular Biology

Background:

  • Skin aging results from intrinsic and extrinsic factors, including reactive oxygen species (ROS) and mitochondrial DNA (mtDNA) mutations.
  • Demographic shifts increase the demand for clinical solutions to age-related skin functional deficits.

Purpose of the Study:

  • To review human skin aging pathways and the protective role of ferulic acid, referencing current patents.
  • To explore the antioxidant mechanisms and signaling pathways influenced by ferulic acid relevant to skin aging.

Main Methods:

  • Literature review of skin aging mechanisms, including oxidative stress, telomere shortening, and glycation.
  • Analysis of ferulic acid's antioxidant properties, including free radical scavenging, ROS suppression, and metal ion chelation.
  • Examination of ferulic acid's impact on cellular signaling pathways like AMPK, TGF-β/Smad, and NF-κB.

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Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
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A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
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Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
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Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
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Main Results:

  • Ferulic acid acts as a potent antioxidant by neutralizing free radicals and inhibiting ROS production.
  • It chelates metal ions and modulates enzyme activity, enhancing antioxidant defenses and reducing pro-oxidant enzymes.
  • Ferulic acid influences key aging pathways, including AMPK signaling for cellular homeostasis and inhibiting UV-induced collagen degradation via TGF-β/Smad.

Conclusions:

  • Ferulic acid demonstrates significant potential as a therapeutic agent for combating skin aging due to its multifaceted antioxidant and signaling pathway modulating effects.
  • Understanding ferulic acid's mechanisms provides insights for developing novel clinical remedies against age-related skin functional decline.