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ChagasDB: 80 years of publicly available data on the molecular host response to Trypanosoma cruzi infection in a

Pauline Brochet1, Jean-Christophe Mouren1, Laurent Hannouche2

  • 1Institut National de la Santé Et de la Recherche Médicale (INSERM), Unité Mixte de Recherche (UMR)_1090, Aix Marseille Université, TAGC Theories and Approaches of Genomic Complexity, Institut MarMaRa, Marseille 13288, France.

Database : the Journal of Biological Databases and Curation
|May 23, 2023
PubMed

Insights

Chagas disease research is advanced by ChagasDB, a manually curated database of molecules affected by Trypanosoma cruzi infection. This accessible online resource aids scientists studying this widespread parasitic disease.

Area of Science:

  • Parasitology
  • Molecular Biology
  • Bioinformatics

Background:

  • Chagas disease, caused by Trypanosoma cruzi, affects millions globally, leading to severe chronic conditions with no current treatment.
  • Approximately 10,000 deaths occur annually, with 30% of infected individuals developing serious cardiac, digestive, or neurological complications.

Purpose of the Study:

  • To create a centralized, accessible database (ChagasDB) to facilitate Chagas disease research.
  • To compile and organize information on host molecules deregulated by Trypanosoma cruzi infection.

Main Methods:

  • Manual curation of all PubMed-referenced papers on Chagas disease.
  • Retrieval and inclusion of data on deregulated host molecules following T. cruzi infection.
  • Development of a user-friendly website for database accessibility.

Main Results:

  • Construction of ChagasDB, a comprehensive database of host molecules affected by T. cruzi.
  • A publicly accessible website (https://chagasdb.tagc.univ-amu.fr) has been launched.
  • The database provides a valuable resource for researchers studying Chagas disease.

Conclusions:

  • ChagasDB significantly enhances the accessibility of curated data for Chagas disease research.
  • The database serves as a crucial tool for understanding host-parasite interactions and identifying potential therapeutic targets.
  • Facilitating research through ChagasDB is vital for developing effective treatments for Chagas disease.

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