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Updated: Jul 29, 2025

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
Published on: September 14, 2018
Targeted delivery of alcohol-containing payloads with antibody-drug conjugates
Katja E Grier1, Anders H Hansen1, Christina S Haxvig1
1Department of Chemistry, Technical University of Denmark, Lyngby DK-2800, Denmark. kaqvo@kemi.dtu.dk.
Abstract:
We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.
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