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Osteoarthritis models: From animals to tissue engineering.

Hongyuan Dou1, Shuhan Wang2, Jiawei Hu1

  • 1School of Biomedical Engineering, Shenzhen Campus, Sun Yat-Sen University, Shenzhen, China.

Journal of Tissue Engineering
|May 24, 2023
PubMed
Summary

Developing reliable osteoarthritis (OA) models is crucial for understanding disease mechanisms and evaluating treatments. This review highlights animal and engineered models, emphasizing engineered options for future OA research.

Keywords:
Osteoarthritisanimal modeldrug evaluationengineering modelpathogenic mechanismtissue engineering

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Area of Science:

  • Biomedical Engineering
  • Rheumatology
  • Pathology

Background:

  • Osteoarthritis (OA) is a complex degenerative joint disease with poorly understood pathogenic mechanisms.
  • Current therapeutic strategies for OA are limited due to the lack of precise disease models.
  • Accurate models are essential for advancing OA pathogenesis research and drug development.

Purpose of the Study:

  • To review the importance and development of osteoarthritis (OA) models.
  • To analyze the advantages and disadvantages of various OA models, including animal and engineered types.
  • To emphasize the potential of advanced engineered models in OA research.

Main Methods:

  • Literature review of existing osteoarthritis (OA) models.
  • Comparative analysis of animal models and engineered models.
  • Focus on pathogenesis and pathology in model evaluation.

Main Results:

  • Various animal models exist but have limitations in fully recapitulating human OA.
  • Engineered OA models offer promising alternatives with enhanced relevance.
  • Challenges remain in developing perfectly reliable OA models.

Conclusions:

  • Reliable OA models are critical for understanding disease progression and testing interventions.
  • Engineered models represent a significant advancement and potential future direction for OA research.
  • Further development is needed to overcome challenges in creating accurate and predictive OA models.