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Related Experiment Video

Updated: Jul 29, 2025

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Hepatitis E as a Zoonosis.

Fusheng Si¹, Frederik Widén², Shijuan Dong³

¹Institute of Animal Husbandry and Veterinary Science, Shanghai Academy of Agricultural Sciences, Shanghai, China.

Advances in Experimental Medicine and Biology

|May 24, 2023

Summary

Hepatitis E virus (HEV) genotypes 3, 4, 7, and C1 are confirmed zoonotic, originating from animals like pigs and camels. Understanding these zoonotic HEV strains is crucial for effective surveillance and prevention strategies.

Keywords:

Camel HEV Hepatitis E virus Rabbit HEV Rat HEV Swine HEV Zoonosis

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Area of Science:

Virology
Zoonotic Diseases
Public Health

Background:

Hepatitis E virus (HEV) classification includes 2 genera, 5 species, and 13 genotypes.
Zoonotic HEV strains pose a significant public health concern, causing sporadic human diseases.
Identified zoonotic HEV genotypes include 3, 4, 7, and C1, with genotypes 5 and 8 as likely zoonotic.

Purpose of the Study:

To provide a detailed overview of zoonotic HEV.
To discuss the prevalence, transmission, phylogenetic relationships, and detection of various zoonotic HEV genotypes.
To offer insights into HEV strains from swine, wild boar, rabbit, camel, and rat.

Main Methods:

Review and synthesis of existing data on zoonotic HEV.
Taxonomic classification of HEV within the Hepeviridae family.
Detailed analysis of specific zoonotic HEV genotypes and their hosts.

Main Results:

Four HEV genotypes (3, 4, 7, C1) are confirmed zoonotic, infecting humans via animal hosts like pigs, boars, deer, rabbits, camels, and rats.
Zoonotic HEVs are taxonomically placed in the Orthohepevirus genus.
Information on prevalence, transmission, phylogeny, and detection methods for key zoonotic HEV strains is presented.

Conclusions:

A comprehensive understanding of zoonotic HEV is essential for researchers.
This knowledge aids in developing effective surveillance and prevention strategies for HEV.
Further research into HEV hosts and transmission dynamics is warranted.