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Niosomes: A Smart Drug Delivery System for Brain Targeting
Sandesh Varshney1, Md Aftab Alam1, Awaneet Kaur1
1Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.
Pharmaceutical Nanotechnology
|May 25, 2023
Summary
Niosomes, lipid-based nanovesicles, show promise for brain drug delivery, enhancing stability and bioavailability for conditions like ASOs and AAV vectors. Further research is needed to optimize formulations and overcome scale-up challenges for clinical use.
Area of Science:
- Nanotechnology
- Pharmaceutics
- Neuroscience
Background:
- Niosomes are lipid-based nanovesicles explored as drug delivery systems.
- They offer improved stability, bioavailability, and targeted administration for various agents, including antisense oligonucleotides (ASOs) and adeno-associated virus (AAV) vectors.
Purpose of the Study:
- To review the current applications of niosomes in treating brain disorders.
- To highlight the potential of niosomes as nanocarriers for brain-targeted drug delivery.
Main Methods:
- Literature review of niosome applications in brain drug delivery.
- Analysis of niosome formulation advantages and challenges.
Main Results:
- Niosomes demonstrate potential for delivering agents like ASOs and AAV vectors to the brain.
- Advantages include enhanced stability and bioavailability.
- Challenges remain in formulation optimization, stability, release profiles, and commercialization.
Conclusions:
- Niosomes represent a promising nanocarrier for targeted brain drug delivery.
- Further research is essential to optimize niosome formulations and address scale-up issues for clinical translation in treating neurological disorders.
Keywords:
Non-ionic surfactantsbioavailabilitycharged moleculecholesteroldrug deliverynanomaterialsneuropeptides.More Related Videos
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