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Leukemic Optic Neuropathy in Pediatric Patients: A Case Series
Journal of Pediatric Ophthalmology and Strabismus
|May 25, 2023
Summary
Pediatric leukemic optic neuropathy often presents during remission, with variable diagnostic findings. Early clinical suspicion and prompt treatment are crucial for preserving vision in children with leukemia.
Area of Science:
- Ophthalmology
- Pediatric Oncology
- Neurology
Background:
- Leukemic optic neuropathy is a rare but serious complication of leukemia in children.
- Understanding its presentation, clinical course, and treatment is vital for timely intervention.
Purpose of the Study:
- To characterize the presentation, clinical course, and treatment of pediatric leukemic optic neuropathy.
- To identify key diagnostic and management considerations for this condition.
Main Methods:
- Retrospective review of 11 children with leukemia and optic nerve infiltration treated at a tertiary children's hospital.
- Data collected included demographics, cancer history, ophthalmologic findings, treatment, and outcomes.
Main Results:
- The majority of patients (81.8%) presented with optic nerve infiltration during remission.
- Cerebrospinal fluid (CSF) was positive in 36.4%, and MRI showed enhancement/enlargement in 72.7%.
- Most patients (72.7%) received emergent radiation therapy for optic nerve infiltration.
Conclusions:
- Negative CSF and variable MRI findings highlight the importance of clinical suspicion for leukemic optic neuropathy.
- Prompt ophthalmologic evaluation and urgent treatment are essential for vision preservation and systemic disease management in leukemia patients.
