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Published on: May 4, 2021
Nasal nitric oxide in healthy Chinese children aged 6-18 years
Yufen Wu1, Hao Zhang1, Jinrong Wang2
1Department of internal medicine, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Insights
This study establishes normal fractional concentration of nasal nitric oxide (FnNO) values for Chinese children aged 6-18. Findings provide crucial clinical diagnostic references for pediatric respiratory health.
Area of Science:
- Pediatric Pulmonology
- Respiratory Physiology
- Biomarkers
Background:
- Nitric oxide (NO) plays a role in airway function.
- Establishing normal reference ranges for biomarkers is essential for accurate clinical interpretation.
- Fractional concentration of nasal nitric oxide (FnNO) is a non-invasive marker of upper airway inflammation.
Purpose of the Study:
- To determine the normal range of fractional concentration of nasal nitric oxide (FnNO) in Chinese children aged 6-18 years.
- To provide a reference standard for clinical diagnosis in pediatric populations.
- To investigate factors influencing FnNO levels in this demographic.
Main Methods:
- A cross-sectional study involving 2,580 children (aged 6-18 years) from 12 centers across China.
- Fractional concentration of nasal nitric oxide (FnNO) was measured using the Nano Coulomb Breath Analyzer, adhering to ATS/ERS guidelines.
- Height, weight, age, and sex were recorded for data analysis.
Main Results:
- The mean FnNO value for Chinese children aged 6-18 years was 454.5 ± 176.2 ppb, with 95% falling between 134.5-844.0 ppb.
- Prediction equations for FnNO were developed: for ages 6-11 years, FnNO = 298.881 + 17.974 × age; for ages 12-18 years, FnNO = 579.222 - 30.332 × (sex [0=male, 1=female]) - 5.503 × age.
- Age and sex were identified as significant predictors of FnNO in children aged 12-18 years.
Conclusions:
- This study provides normative FnNO values and prediction equations for Chinese children.
- The findings offer valuable reference data for the clinical assessment of pediatric respiratory conditions.
- Age and sex-specific reference ranges enhance the diagnostic utility of FnNO measurements in children.
Objectives:
To obtain the normal values of fractional concentration of nasal nitric oxide in Chinese children aged 6-18 years, so as to provide reference for clinical diagnosis.
Methods:
2,580 out of 3,200 children (1,359 males and 1,221 females), whom were included from 12 centers around China were taken tests, their height and weight were also recorded. Data were used to analyze the normal range and influencing factors of fractional concentration of nasal nitric oxide values.
Measurements:
Data was measured using the Nano Coulomb Breath Analyzer (Sunvou-CA2122, Wuxi, China), according to the American Thoracic Society/European Respiratory Society (ATS/ERS) recommendations.
Main Results:
We calculated the normal range and prediction equation of fractional concentration of nasal nitric oxide values in Chinese children aged 6-18 years. The mean FnNO values of Chinese aged 6-18 yrs was 454.5 ± 176.2 ppb, and 95% of them were in the range of 134.5-844.0 ppb. The prediction rule of FnNO values for Chinese children aged 6-11 yrs was: FnNO = 298.881 + 17.974 × age. And for children aged 12-18 yrs was: FnNO = 579.222-30.332 × (male = 0, female = 1)-5.503 × age.
Conclusions:
Sex and age were two significant predictors of FnNO values for Chinese children(aged 12-18 yrs). Hopefully this study can provide some reference value for clinical diagnosis in children.
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