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Pathophysiological role of BACH transcription factors in digestive system diseases

Qianben Song1,2, Xin Mao1,2, Mengjia Jing1,2

  • 1Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Frontiers in Physiology
|May 25, 2023
PubMed

Insights

BTB and CNC homologous (BACH) proteins regulate gene transcription and cellular processes. This review focuses on BACH protein functions in the digestive system and their role in diseases like cancer and inflammation.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • BTB and CNC homologous (BACH) proteins, including BACH1 and BACH2, are transcription factors crucial for cellular regulation.
  • They heterodimerize with small musculoaponeurotic fibrosarcoma (MAF) proteins to modulate gene transcription.
  • BACH proteins influence diverse physiological processes and are implicated in various pathologies.

Purpose of the Study:

  • To review the multifaceted roles of BACH proteins within the human digestive system.
  • To elucidate the mechanisms by which BACH proteins regulate digestive system functions and diseases.
  • To identify regulators of BACH proteins for potential therapeutic targeting in digestive diseases.

Main Methods:

  • Literature review of studies on BACH proteins.
  • Analysis of BACH protein interactions and regulatory networks.
  • Synthesis of information on BACH protein involvement in digestive system physiology and pathology.

Main Results:

  • BACH proteins play significant roles in the liver, gallbladder, esophagus, stomach, intestines, and pancreas.
  • They directly and indirectly regulate genes involved in inflammation, angiogenesis, and epithelial-mesenchymal transition.
  • BACH proteins are modulated by various factors including proteins, miRNAs, LncRNAs, and iron.

Conclusions:

  • BACH proteins are key regulators in the digestive system, impacting both normal function and disease development.
  • Understanding BACH protein regulation offers potential for targeted drug development for digestive diseases.
  • Further research into BACH protein networks is warranted for therapeutic advancements.
Keywords:
BACH1BACH2cancerdigestive system diseasestranscription factor

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