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Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

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PIK3CA-related overgrowth spectrum (PROS): a rare case report

Cedra Kalo¹, Firas Khana², Aya Jazmati¹

¹Departments of Dermatology and Venereology.

Annals of Medicine and Surgery (2012)

|May 25, 2023

Abstract:

Case report.

Introduction And Importance:

The purpose of this study is to report an extremely rare case of PIK3CA-related overgrowth spectrum.

Case Presentation:

A 12-year-old boy presented with severe overgrowth in the left lower limb causing severe movement restriction and decreased quality of life.

Interventions And Outcome:

Episodes of myiasis were manually treated through mechanical removal and the patient was placed on rapamycin therapy for managing vascular malformations.

Conclusion:

CLOVES syndrome is a rare overgrowth disorder that can be confused with other overgrowth syndromes; however, clinical and imaging findings are essential for pinpointing the correct diagnosis as genetic sequencing may not always prove reliable.

Keywords:

CLOVES syndrome PIK3CA-related overgrowth spectrum (PROS)case report computed tomography angiography magnetic resonance imaging (MRI)

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