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High Throughput Single-cell and Multiple-cell Micro-encapsulation

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Published on: June 15, 2012

Lubricated Interfaces Enabling Simultaneous Pulsatile and Continuous Chemical Release Modes.

Angana Borbora¹, Yang Xu², Souradeep Dey³

¹Bio-Inspired Polymeric Materials Lab, Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India.

Advanced Materials (Deerfield Beach, Fla.)

|May 25, 2023

Summary

This study introduces a novel liquid-crystal-infused porous surface (LCIPS) material capable of simultaneous pulsatile and continuous chemical release. This breakthrough enables advanced applications in programmed reactions and targeted disease treatments.

Keywords:

continuous release liquid crystals lubricated interfaces porous coatings pulsatile release

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Area of Science:

Materials Science
Biomedical Engineering
Chemical Engineering

Background:

Simultaneous pulsatile and continuous chemical release from a single system is crucial for advanced applications but remains challenging.
Existing materials often struggle to achieve dual-mode release, limiting their therapeutic and industrial potential.

Purpose of the Study:

To develop a novel material system capable of simultaneous pulsatile and continuous chemical release.
To demonstrate controlled, dual-mode release of distinct bioactive molecules for therapeutic applications.

Main Methods:

Utilizing a liquid-crystal-infused porous surface (LCIPS) with two distinct chemical loading strategies.
Implementing liquid crystal (LC) mesophase-dependent release for continuous delivery.
Incorporating micrometer-sized aqueous droplets for phase-transition-activated pulsatile release.

Main Results:

Successfully demonstrated simultaneous pulsatile and continuous release from the LCIPS material.
Showcased controlled, programmed release of distinct molecules based on loading methods.
Validated the release of tetracycline and dexamethasone, exhibiting antibacterial and immunomodulatory activities.

Conclusions:

The developed LCIPS material effectively achieves simultaneous dual-mode chemical release.
This technology offers a versatile platform for programmed delivery of bioactive molecules.
Potential applications include chronic wound healing and biomedical implant coatings.