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Modular, cement-free, customized headpost and connector-chamber implants for macaques.

Eleni Psarou¹, Julien Vezoli¹, Marieke L Schölvinck¹

¹Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany.

Journal of Neuroscience Methods

|May 25, 2023

Summary

This summary is machine-generated.

We developed long-lasting, cement-free titanium implants for primate neurophysiology. These modular headpost and connector-chamber implants demonstrate excellent stability and condition for over 9 years, improving animal welfare.

Keywords:

Chronic implants Connector chamber Headpost Macaque Osseointegration Refinement

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Area of Science:

Neuroscience
Primate Research
Surgical Implants

Background:

Chronic cranial implants are essential for neurophysiological studies in awake macaques.
Traditional implants often involve headposts for stabilization and connector chambers for electrode housing.

Purpose of the Study:

To present novel, long-lasting, modular, and cement-free titanium headpost and connector-chamber implants.
To enhance implant longevity, handling safety, and animal welfare in primate research.

Main Methods:

A two-step surgical approach for implanting a baseplate followed by a percutaneous part.
Utilizing a punch tool for precise skin incisions and a remote headposting technique.
Developing both manually bent and CNC-milled baseplates for modular headposts and footless connector chambers.

Main Results:

Successful implantation in twelve adult male macaques with no implant failures reported.
Demonstrated excellent headpost stability and implant condition, with some lasting over 9 years.
The connector chamber achieved a minimized footprint on the skull.

Conclusions:

The optimized implants offer stability and health for at least 9 years, exceeding typical experimental durations.
These advancements minimize implant-related complications and the need for corrective surgeries.
The improved implant design significantly enhances animal welfare in neurophysiological research.