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Related Experiment Video

Updated: Jun 13, 2026

Hybrid Microdrive System with Recoverable Opto-Silicon Probe and Tetrode for Dual-Site High Density Recording in Freely Moving Mice
08:57

Hybrid Microdrive System with Recoverable Opto-Silicon Probe and Tetrode for Dual-Site High Density Recording in Freely Moving Mice

Published on: August 10, 2019

A hybrid micro-ECoG for functionally targeted multi-site and multi-scale investigation.

Patrick Jendritza1, Rickard Liljemalm2, Thomas Stieglitz3

  • 1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Deutschordenstraße 46, 60528 Frankfurt, Germany; International Max Planck Research School for Neural Circuits, Max-von-Laue-Straße 4, 60438 Frankfurt, Germany; Else Kröner Fresenius Center for Optogenetic Therapies, University Medical Center Göttingen, Göttingen, Germany; Institute for Auditory Neuroscience, University Medical Center Göttingen, Göttingen, Germany; Visual Circuits & Interfaces group, German Primate Center, Göttingen, Germany.

Cell Reports Methods
|June 11, 2026
PubMed
Summary
This summary is machine-generated.

New hybrid micro-electrocorticography (μECoG) arrays enable simultaneous recording of brain activity across multiple scales. This technology bridges local neural dynamics with global brain networks for advanced systems neuroscience research.

Keywords:
CP: biotechnologyCP: neuroscienceECoGLFPbrainelectrocorticographymultimodalneuroscienceoptogeneticsprimatesensory codingtopography

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Last Updated: Jun 13, 2026

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Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

Published on: May 23, 2025

Area of Science:

  • Systems Neuroscience
  • Neurotechnology
  • Electrophysiology

Background:

  • Brain function integrates activity across diverse spatial and temporal scales.
  • Understanding integrated brain function necessitates tools for recording from distributed, connected neural populations.
  • Bridging local neuronal activity with global brain dynamics is crucial for systems neuroscience.

Purpose of the Study:

  • To introduce high-density, hybrid micro-electrocorticography (μECoG) arrays for multi-scale brain activity studies.
  • To demonstrate the utility of these arrays in functional mapping and multi-area laminar recordings.
  • To showcase their application in investigating cortico-cortical interactions via optogenetic stimulation.

Main Methods:

  • Development of hybrid μECoG arrays combining silicone elastomers and polyimide films.
  • Utilizing arrays for high-throughput functional mapping in rodents and non-human primates.
  • Performing multi-area laminar recordings guided by functional maps.
  • Implementing local and feedforward optogenetic stimulation for studying neural interactions.

Main Results:

  • Demonstrated successful functional mapping in rats, cats, and marmosets.
  • Showcased how functional maps guide precise insertion of intracortical arrays for dense local sampling.
  • Validated the arrays' capability for multi-area laminar recordings.
  • Confirmed the utility of hybrid μECoG arrays for investigating cortico-cortical interactions.

Conclusions:

  • Hybrid μECoG arrays offer a powerful tool for multi-scale brain activity recording.
  • This technology facilitates bridging local and global brain dynamics.
  • The developed arrays represent a significant advancement for systems neuroscience research.