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MoS2-Nanoflower and Nanodiamond Co-Engineered Surface Plasmon Resonance for Biosensing
Yaofei Chen1,2, Xin Xiong1,2, Yu Chen1,2
1Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Jinan University, Guangzhou 510632, China.
Biosensors
|May 26, 2023
Summary
This study introduces a novel method to boost the sensitivity of surface plasmon resonance (SPR) sensors using molybdenum disulfide nanoflowers (MoS2 NF) and nanodiamonds (ND). This enhancement is crucial for biological and medical applications, enabling more accurate detection of analytes.
Area of Science:
- Nanotechnology
- Biomedical Engineering
- Analytical Chemistry
Background:
- Surface plasmon resonance (SPR) sensors are vital in biological and medical diagnostics.
- Enhancing SPR sensor sensitivity is a key research objective for improved detection limits.
- Existing SPR platforms can be limited by sensitivity in complex biological samples.
Purpose of the Study:
- To develop and demonstrate a novel sensitivity enhancement scheme for SPR sensors.
- To investigate the combined effect of MoS2 nanoflowers (MNF) and nanodiamonds (ND) on SPR sensor performance.
- To validate the enhanced sensor's efficacy in biological assays and virus detection.
Main Methods:
- Fabrication of a co-engineered plasmonic surface by depositing MNF and ND overlayers onto a gold SPR chip.
- Optimization of MNF and ND deposition times to achieve maximum sensitivity.
- Characterization of the modified SPR chip using techniques like SEM and AFM (implied).
- Performance evaluation through bulk refractive index (RI) sensitivity measurements and IgG immunoassay.
- Application testing for pseudorabies virus detection in serum.
Main Results:
- Achieved a significant enhancement in bulk RI sensitivity from 9682 to 12,219 nm/RIU under optimal MNF and ND deposition.
- Demonstrated a twofold increase in sensitivity for IgG immunoassay compared to a bare gold surface.
- Confirmed that sensitivity improvement is due to enhanced sensing fields and increased antibody loading.
- Showcased the versatility of NDs for specific sensor functionalization compatible with gold surfaces.
- Successfully applied the enhanced SPR sensor for pseudorabies virus detection in serum.
Conclusions:
- The proposed MNF and ND co-engineering strategy effectively enhances SPR sensor sensitivity.
- This method offers a simple, flexible, and efficient approach for improving SPR-based biosensing.
- The enhanced SPR sensor holds significant potential for sensitive and specific detection in clinical diagnostics and disease surveillance.
