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A Bibliometric and In Silico-Based Analysis of Anti-Lung Cancer Compounds from Sea Cucumber
Afshin Zare1, Safoura Izanloo2,3, Sajed Khaledi4
1The PerciaVista Biotechnology Company, Shiraz 71676-83745, Iran.
Abstract:
Lung cancer is one of the most lethal malignancies in the world. However, current curative approaches for treating this type of cancer have some weaknesses. Therefore, scientists are attempting to discover new anti-lung cancer agents. Sea cucumber is a marine-derived source for discovering biologically active compounds with anti-lung cancer properties. To explore the anti-lung cancer properties of sea cucumber, we analyzed surveys using VOSviewer software and identified the most frequently used keywords. We then searched the Google Scholar database for compounds with anti-lung cancer properties within that keyword family. Finally, we used AutoDock 4 to identify the compounds with the highest affinity for apoptotic receptors in lung cancer cells. The results showed that triterpene glucosides were the most frequently identified compounds in studies examining the anti-cancer properties of sea cucumbers. Intercedenside C, Scabraside A, and Scabraside B were the three triterpene glycosides with the highest affinity for apoptotic receptors in lung cancer cells. To the best of our knowledge, this is the first time that anti-lung cancer properties of sea cucumber-derived compounds have been examined in in silico conditions. Ultimately, these three components displayed anti-lung cancer properties in in silico conditions and may be used for the manufacture of anti-lung cancer agents in the near future.
Insights
Sea cucumbers yield potential anti-lung cancer compounds. Triterpene glycosides, specifically Intercedenside C, Scabraside A, and Scabraside B, show high affinity for lung cancer apoptotic receptors in silico.
Area of Science:
- Marine Natural Products Chemistry
- Computational Drug Discovery
- Oncology
Background:
- Lung cancer remains a leading cause of cancer-related mortality worldwide.
- Existing lung cancer treatments possess limitations, necessitating novel therapeutic strategies.
- Marine organisms, such as sea cucumbers, are promising sources for discovering new anti-cancer agents.
Purpose of the Study:
- To identify sea cucumber-derived compounds with potential anti-lung cancer activity.
- To computationally evaluate the binding affinity of these compounds to apoptotic receptors in lung cancer cells.
Main Methods:
- Bibliometric analysis of sea cucumber anti-cancer research using VOSviewer.
- Literature search on Google Scholar for relevant compounds.
- In silico molecular docking using AutoDock 4 to assess receptor affinity.
Main Results:
- Triterpene glycosides were identified as the most prevalent compounds in sea cucumber anti-cancer studies.
- Intercedenside C, Scabraside A, and Scabraside B exhibited the highest binding affinity to lung cancer apoptotic receptors.
- This study represents the first in silico investigation of sea cucumber compounds against lung cancer.
Conclusions:
- Intercedenside C, Scabraside A, and Scabraside B demonstrate significant in silico anti-lung cancer potential.
- These compounds may serve as lead candidates for the development of novel anti-lung cancer therapeutics.
- Further research is warranted to validate these findings in preclinical and clinical settings.
