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Related Experiment Videos

Polymeric dyes: limitations in their use as reference markers in postcibal studies.

M Fried, J H Meyer

    Journal of Pharmaceutical Sciences
    |April 1, 1986
    PubMed
    Summary

    Polyporphyre and polycyanine dyes are not suitable for post-meal intestinal studies. These polymeric dyes bind to food particles and degrade in acidic conditions, unlike polyethylene glycol 4000.

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    Area of Science:

    • Gastroenterology
    • Pharmacology

    Background:

    • Polymeric dyes like polyporphyre and polycyanine have been proposed as markers for intestinal perfusion.
    • Their utility in postcibal (after meal) intestinal studies requires further investigation.

    Purpose of the Study:

    • To evaluate the suitability of polyporphyre and polycyanine as markers for postcibal intestinal studies.
    • To compare their performance against polyethylene glycol 4000 (PEG 4000), a standard nonabsorbable marker.

    Main Methods:

    • In vitro adsorption of dyes to cooked liver particles.
    • In vivo study in dogs with midgut fistulas following a meat meal.
    • Assessment of dye color stability at low pH levels.

    Main Results:

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  • Both polyporphyre and polycyanine showed quantitative adsorption to cooked liver particles in vitro.
  • In dogs, polycyanine was completely taken up by food particles after a meat meal.
  • Polycyanine exhibited color instability below pH 3.

    • Conclusions:

    • Polyporphyre and polycyanine are not ideal markers for postcibal intestinal studies due to adsorption to food particles.
    • Their performance is inferior to PEG 4000 in the presence of solid food in the intestine.
    • Polycyanine's pH-dependent color instability further limits its application.