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Maternal Mineral Nutrition Regulates Fetal Genomic Programming in Cattle: A Review
Muhammad Anas1, Wellison J S Diniz2, Ana Clara B Menezes3
1Department of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 36849, USA.
Metabolites
|May 26, 2023
Summary
Maternal mineral nutrition impacts fetal development and lifetime productivity in cattle. This review explores how minerals regulate the fetal epigenome, influencing organ development and metabolic health.
Area of Science:
- Reproductive Biology
- Epigenetics
- Animal Science
Background:
- Maternal nutrition significantly influences offspring health and productivity, a concept central to the developmental origins of health and disease (DOHaD).
- While macronutrients have been extensively studied, the role of micronutrients, particularly minerals, in fetal programming remains underexplored in livestock, especially cattle.
- Understanding mineral-driven epigenetic regulation is crucial for optimizing livestock development and productivity.
Purpose of the Study:
- To review the impact of maternal dietary minerals on fetal developmental programming in cattle from embryonic to postnatal stages.
- To elucidate the role of minerals in regulating the fetal epigenome and its connection to organ development.
- To highlight key regulatory pathways influenced by maternal mineral supply and epigenomic crosstalk in cattle.
Main Methods:
- Literature review synthesizing findings from cattle research, model animals, cell lines, and other livestock species.
- Analysis of existing data on mineral-specific effects on gene regulation and epigenetic modifications during gestation.
- Comparative approach to draw parallels between different species and experimental models.
Main Results:
- Maternal minerals play a coordinated role in feto-maternal genomic regulation, essential for pregnancy establishment and organogenesis.
- Specific minerals influence the development and function of critical fetal tissues, including the liver, skeletal muscle, and placenta.
- Dietary mineral supply interacts with epigenomic mechanisms to program fetal development.
Conclusions:
- Maternal mineral nutrition is a critical determinant of fetal programming and long-term productivity in cattle.
- Minerals are key regulators of the fetal epigenome, impacting the development of vital organs and tissues.
- Further research into mineral-epigenome interactions can inform strategies for improving livestock health and performance.
Keywords:
developmental biologyepigeneticsepigenomeessential nutrientsgeneticsmacromineralsmicromineralsrestricted nutritionMore Related Videos
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