Related Experiment Video

Updated: Jul 29, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

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The roles, molecular interactions, and therapeutic value of CDK16 in human cancers

Xiao Wang1, Ruiqi Liu2, Shuang Li3

  • 1Cancer Center, Department of Medical Oncology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|May 26, 2023
PubMed

Insights

Cyclin-dependent kinase 16 (CDK16) is crucial in cell functions and cancer development. This review details CDK16

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Cyclin-dependent kinase 16 (CDK16) is an orphan kinase involved in numerous cellular processes.
  • CDK16 is implicated in cell cycle regulation, trafficking, and growth.
  • Its role as a potential oncoprotein and its association with X-linked diseases are noted.

Purpose of the Study:

  • To review the multifaceted roles of CDK16 in human cancers.
  • To elucidate the underlying mechanisms of CDK16's involvement in tumorigenesis.
  • To highlight CDK16 as a potential biomarker for cancer diagnosis and prognosis.

Main Methods:

  • Literature review and synthesis of existing research on CDK16.
  • Analysis of CDK16's functions in various cellular pathways.
  • Examination of CDK16's expression and activity in different cancer types.

Main Results:

  • CDK16 is actively involved in cell proliferation, metastasis, and apoptosis.
  • Dysregulation of CDK16 is observed in lung, prostate, breast cancers, melanoma, and hepatocellular carcinoma.
  • Cyclin Y or Cyclin Y-like 1 regulates CDK16 activity.

Conclusions:

  • CDK16 plays a significant role in the development and progression of various human cancers.
  • Understanding CDK16 mechanisms offers insights into cancer biology.
  • CDK16 presents a promising target for cancer diagnostics and therapeutics.
Keywords:
CDK16CancerCell cyclePCTAIRE1PCTK1

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