Diagnosing Disorders of Hypopigmentation and Depigmentation in Patients with Skin of Color
Related Experiment Video
Updated: Jul 29, 2025

Quantification of Hypopigmentation Activity In Vitro
Published on: March 6, 2019
Marissa S Ceresnie1, Sarah Gonzalez2, Iltefat H Hamzavi1
1Department of Dermatology, Multicultural Clinic, Henry Ford Health, 3031 West Grand Boulevard, Suite 700, Detroit, MI 48202, USA.
Abstract:
Skin hypopigmentation and depigmentation disorders are a top concern for patients with skin of color seeking care from a dermatologist. The visual contrast between involved and uninvolved skin in these disorders makes them particularly burdensome for patients with skin of color. These disorders may have a wide differential of diagnosis, as patients with skin of color may present differently or more frequently than White patients for certain conditions. Clues from a comprehensive history and physical examination with standard lighting and a Wood's light are essential for clinching the diagnosis, although a biopsy may be warranted in special cases.
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