Related Experiment Video
Updated: Jul 29, 2025
09:50
A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice
Published on: November 2, 2019
8.1K
Secondary Lymphedema: Clinical Interdisciplinary Tricks to Overcome an Intriguing Disease
Sylvain Mukenge1, Daniela Negrini2, Ottavio Alfieri1
1Department of Cardiothoracic-Vascular Surgery, Vita-Salute San Raffaele University, 20132 Milano, Italy.
Biology
|May 27, 2023
Summary
Secondary lymphedema, characterized by fluid buildup and tissue changes, significantly impacts patients. Minimally invasive microsurgery offers promising long-term solutions for severe cases, particularly in limbs and genitals.
Area of Science:
- Vascular Surgery
- Microsurgery
- Lymphedema Research
Background:
- Secondary lymphedema involves tissue fluid accumulation, matrix alteration, debris deposition, and inflammation.
- It commonly affects limbs and genitals post-oncological surgery, or due to other conditions like trauma or congenital malformations.
- Current treatments range from conservative measures to advanced lymphatic microsurgery.
Purpose of the Study:
- To review evolving peripheral lymphedema types and symptom-specific treatments.
- To highlight advanced lymphatic microsurgical techniques for long-term secondary lymphedema management.
- To emphasize the role of microsurgery in promoting new lymphatic vessel growth.
Main Methods:
- Review of current literature on secondary lymphedema.
- Analysis of established and emerging microsurgical techniques.
- Focus on lymphatic grafting and lympho-venous shunt applications.
Main Results:
- Minimally invasive microsurgery shows potential for long-term healing of severe secondary lymphedema.
- Techniques like lymphatic grafting and lympho-venous shunts are key evolving approaches.
- Microsurgery may stimulate the development of new lymphatic networks.
Conclusions:
- Minimally invasive microsurgery represents a significant advancement in treating secondary lymphedema.
- Further research is crucial to optimize microsurgical approaches for the lymphatic vascular system.
- These techniques offer hope for improved long-term outcomes in affected patients.
Related Concept Videos
01:26Varicose Veins II: Diagnostic Studies and Interprofessional Care
19
Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
19
01:15Development of the Lymphatic System
837
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
837
01:27Peripheral Artery Disease III: Interprofessional Care
14
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
14
01:16Lymphatic Vessels and Lymph Transport
3.8K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
3.8K
01:26Peripheral Artery Disease IV: Nursing Management
15
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
15
01:23Peripheral Artery Disease V: Postoperative Nursing Management
14
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
14