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Strain Imaging and Ventricular Arrhythmia
Caroline Løkke Bjerregaard1,2, Kristoffer Grundtvig Skaarup1,2, Mats Christian Højbjerg Lassen1,2
1Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, 2900 Hellerup, Denmark.
Insights
Identifying patients at risk for sudden cardiac death is crucial. This review explores how cardiac strain imaging, a sensitive technique, can better predict ventricular arrhythmias than ejection fraction, aiding implantable cardioverter-defibrillator selection.
Area of Science:
- Cardiology
- Medical Imaging
- Cardiac Electrophysiology
Background:
- Ventricular arrhythmia is a primary cause of sudden cardiac death.
- Current risk assessment relies on left ventricular ejection fraction, which has limitations.
- Accurate risk stratification is needed to identify candidates for implantable cardioverter-defibrillators.
Purpose of the Study:
- To review the potential of cardiac strain imaging techniques in predicting ventricular arrhythmias.
- To highlight strain measures as alternatives to ejection fraction for risk stratification.
- To discuss the role of speckle-tracking echocardiography in identifying patients at risk.
Main Methods:
- Review of existing literature on strain imaging and ventricular arrhythmias.
- Focus on speckle-tracking echocardiography and its derived strain measures.
- Comparison of strain imaging with ejection fraction in risk prediction.
Main Results:
- Strain imaging, including global longitudinal strain and mechanical dispersion, is a sensitive method for detecting systolic dysfunction.
- These strain measures show promise in identifying patients at risk for ventricular arrhythmias.
- Cardiac mechanics assessed by strain imaging offer a more detailed view than ejection fraction.
Conclusions:
- Strain imaging techniques offer a more sensitive assessment of cardiac function compared to ejection fraction.
- Novel strain measures hold significant potential for improving the prediction of ventricular arrhythmias.
- Further research into strain imaging can optimize the selection of patients for implantable cardioverter-defibrillators.
Abstract:
Ventricular arrhythmia is one of the main causes of sudden cardiac death. Hence, identifying patients at risk of ventricular arrhythmias and sudden cardiac death is important but can be challenging. The indication for an implantable cardioverter defibrillator as a primary preventive strategy relies on the left ventricular ejection fraction as a measure of systolic function. However, ejection fraction is flawed by technical constraints and is an indirect measure of systolic function. There has, therefore, been an incentive to identify other markers to optimize the risk prediction of malignant arrhythmias to select proper candidates who could benefit from an implantable cardioverter defibrillator. Speckle-tracking echocardiography allows for a detailed assessment of cardiac mechanics, and strain imaging has repeatedly been shown to be a sensitive technique to identify systolic dysfunction unrecognized by ejection fraction. Several strain measures, including global longitudinal strain, regional strain, and mechanical dispersion, have consequently been proposed as potential markers of ventricular arrhythmias. In this review, we will provide an overview of the potential use of different strain measures in the context of ventricular arrhythmias.
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