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Precision child health requires tailored approaches due to unique pediatric physiology. This review identifies key challenges and solutions for implementing precision health interventions in children.

Keywords:
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Area of Science:

  • Pediatric precision health
  • Translational science
  • Evidence-based medicine

Background:

  • Precision health personalizes care using genetic differences, improving outcomes for some groups.
  • Broader implementation faces hurdles in evidence development, appraisal, and integration.
  • Existing methods often neglect the unique physiology and socio-biology of children.

Purpose of the Study:

  • To review and synthesize literature on evidence development, appraisal, prioritization, and implementation of precision child health.
  • To identify challenges and solutions for translating precision health into pediatric practice.
  • To highlight the unique considerations for children in precision health research.

Main Methods:

  • Scoping review of literature.
  • Searches conducted in PubMed, Scopus, Web of Science, and Embase.
  • Inclusion criteria focused on pediatrics, precision health, and translational pathways.

Main Results:

  • 74 articles identified challenges and solutions for pediatric precision health interventions.
  • Unique attributes of children significantly impact study design.
  • Key themes for value assessment include clinical benefit, cost-effectiveness, stakeholder values, and ethics.

Conclusions:

  • Addressing challenges requires international data networks and guidelines.
  • Rethinking value assessment methods is crucial.
  • Broadening stakeholder support is essential for effective implementation of precision child health.