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Impacts of Mir146a Genotypes on Bladder Cancer Risk in Taiwan.
Bo-Ren Wang1,2,3, Wen-Shin Chang1,4,5, Cheng-Hsi Liao1,2,3
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404333, Taiwan.
Biomedicines
|May 27, 2023
Summary
Single-nucleotide polymorphisms in microRNA-146a (mir146a) rs2910164 are associated with bladder cancer (BLCA) risk. The GG genotype significantly increases BLCA risk and correlates with higher serum mir146a levels, suggesting its potential as a biomarker.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Bladder cancer (BLCA) is a significant global health concern.
- Genetic variations, particularly single-nucleotide polymorphisms (SNPs) in microRNAs (miRNAs), are increasingly recognized for their role in cancer susceptibility.
- microRNA-146a (mir146a) and microRNA-196a (mir196a) are implicated in various cellular processes, including cancer development.
Purpose of the Study:
- To investigate the association between specific SNPs in mir146a (rs2910164) and mir196a (rs11614913) and the risk of bladder cancer (BLCA) in a Taiwanese population.
- To explore the correlation between mir146a genotypes and serum mir146a expression levels.
Main Methods:
- Genotyping of mir146a rs2910164 and mir196a rs11614913 was performed using PCR-RFLP in 375 BLCA patients and 375 healthy controls.
- Serum expression levels of mir146a were quantified using quantitative RT-PCR.
- Logistic regression analysis was employed to assess the association between genotypes and BLCA risk.
Main Results:
- The mir146a rs2910164 GG genotype was significantly associated with an increased risk of BLCA (OR = 2.17, 95% CI = 1.46-3.21).
- Carriers of the GG or CG genotypes of mir146a rs2910164 exhibited significantly higher serum mir146a levels compared to CC genotype carriers (p < 0.0001), indicating a genotype-phenotype correlation.
- No significant association was found between mir196a rs11614913 and BLCA risk.
Conclusions:
- The genotypes of mir146a rs2910164, particularly the GG variant, may serve as a potential biomarker for predicting bladder cancer risk.
- Further research is warranted to validate these findings and explore the functional mechanisms underlying the association between mir146a polymorphisms and BLCA.
