Related Experiment Video
Updated: Jul 29, 2025
08:34
Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
15.1K
Collagens Regulating Adipose Tissue Formation and Functions.
Iida Jääskeläinen1, Tiina Petäistö1, Elahe Mirzarazi Dahagi2
1ECM-Hypoxia Research Unit, Faculty of Biochemistry and Molecular Medicine, University of Oulu, 90014 Oulu, Finland.
Biomedicines
|May 27, 2023
Summary
Obesity disrupts adipose tissue (AT) function, impacting metabolic health. This review highlights how collagens and extracellular matrix components in AT are crucial for its development, function, and role in metabolic diseases.
Area of Science:
- Biochemistry
- Cell Biology
- Metabolic Research
Background:
- Rising global obesity rates correlate with metabolic diseases like type 2 diabetes, dyslipidemia, and fatty liver.
- Adipose tissue (AT), beyond lipid storage, functions as an endocrine system, and its malfunction contributes to systemic metabolic dysfunction.
- The extracellular matrix (ECM), including the basement membrane (BM), surrounds adipocytes, influencing their function and differentiation.
Purpose of the Study:
- To review the role of vertebrate collagens in adipose tissue development and function.
- To discuss the involvement of other ECM components, such as fibronectin, in adipose tissue.
- To explore the function of adipose tissue collagens in metabolic diseases.
Main Methods:
- Literature review of vertebrate collagens and ECM components in adipose tissue.
- Analysis of the role of collagens in adipocyte differentiation and function.
- Examination of collagen's involvement in adipose tissue fibrosis and metabolic disease.
Main Results:
- Specific collagens, particularly basement membrane-associated collagens, are vital for adipose tissue function and adipocyte differentiation.
- Adipose tissue fibrosis, marked by collagen accumulation, impairs AT function in obesity.
- Fibronectin is another key ECM component influencing adipose tissue biology.
Conclusions:
- Vertebrate collagens are critical regulators of adipose tissue development, function, and ECM integrity.
- Dysfunctional collagens and ECM remodeling in adipose tissue are implicated in obesity-related metabolic diseases.
- Targeting collagens and ECM components may offer therapeutic strategies for metabolic disorders.
Related Concept Videos
01:26Loose Connective Tissue
7.2K
Loose connective tissue is found between many organs. Its main function is to absorb shock and bind tissues together. It also allows water, salts, and various nutrients to diffuse into cells that are embedded in it or present in adjacent tissues.
Adipose Tissue
Adipose tissue consists primarily of fat storage cells called adipocytes and little extracellular matrix. A large number of capillaries present within adipose tissue allow rapid mobilization of lipid molecules. White adipose tissue is...
Adipose Tissue
Adipose tissue consists primarily of fat storage cells called adipocytes and little extracellular matrix. A large number of capillaries present within adipose tissue allow rapid mobilization of lipid molecules. White adipose tissue is...
7.2K
01:02Hypodermis
4.7K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
4.7K
01:26Extracellular Matrix
3.0K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
3.0K
01:17Functions of Connective Tissues
10.8K
Connective tissues perform a broad range of functions in the body. Their primary function is to connect and link different tissues in the body and act as packaging material between tissues. The areolar tissue, a connective tissue prototype, commonly cements various tissue types in diverse body organs. In contrast, adipose tissue cushions internal organs while insulating the body from heat loss.
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
10.8K
01:13Collagens are the Major Structural Proteins of ECM
4.3K
Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
Connective tissue proper includes loose...
4.3K
01:22Connective Tissue Cell Types
3.3K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.3K