Deep Eutectic Solvents Comprising Organic Acids and Their Application in (Bio)Medicine

Area of Science:

• Green Chemistry
• Materials Science
• Biomedical Applications

Background:

• Deep eutectic solvents (DESs) are increasingly studied for their stability, low vapor pressure, and tunable properties.
• While DES applications are reviewed broadly, a specific focus on organic acid-based DESs (OA-DESs) is lacking.
• Many potential biomedical DESs contain organic acids, but their specific properties and applications require further elucidation.

Purpose of the Study:

• To distinguish and review deep eutectic solvents comprising organic acids (OA-DESs) as a specific class.
• To highlight and compare the applications of OA-DESs as antimicrobial agents and drug delivery enhancers.
• To underscore the potential of OA-DESs in biomedical studies.

Main Methods:

• Literature review focusing on OA-DESs.
• Analysis of OA-DESs for antimicrobial and drug delivery applications.
• Comparison of different OA-DES groups based on their applications.

Main Results:

• OA-DESs demonstrate negligible cytotoxicity and adhere to green chemistry principles.
• These solvents are effective as both antimicrobial agents and drug delivery enhancers.
• Specific examples showcase the potential of various OA-DES groups in biomedical contexts.

Conclusions:

• OA-DESs represent a promising category of DESs for targeted biomedical applications.
• Their favorable properties make them suitable for antimicrobial and drug delivery roles.
• Further research into OA-DESs can guide future developments in the field.