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Navigation Guided Biopsy Is as Effective as Frame-Based Stereotactic Biopsy
Dae Hyun Lim1, So Yeon Kim1, Young Cheol Na1
1Department of Neurosurgery, International St Mary's Hospital, Catholic Kwandong University, Incheon 22711, Republic of Korea.
Journal of Personalized Medicine
|May 27, 2023
Summary
Frameless navigation-guided brain biopsy offers 100% diagnostic yield and comparable safety to frame-based methods. This advanced technique may render traditional frame-based stereotactic biopsy obsolete for intracranial procedures.
Area of Science:
- Neurosurgery
- Neurology
- Medical Imaging
Background:
- Stereotactic biopsy is a standard neurosurgical procedure.
- Navigation-guided biopsy, particularly frameless systems, has emerged as a viable alternative.
- Prior research suggests frameless stereotactic biopsy matches frame-based methods in efficacy and safety.
Purpose of the Study:
- To evaluate the diagnostic yield of frameless intracranial biopsy.
- To assess the complication rate associated with frameless navigation-guided biopsy.
- To compare these outcomes with traditional frame-based stereotactic biopsy.
Main Methods:
- Retrospective review of medical records and imaging for patients undergoing biopsy between March 2014 and April 2022.
- Analysis of diagnostic yield and post-operative complications for both frameless and frame-based stereotactic biopsies.
- Statistical comparison of diagnostic rates between the two biopsy techniques.
Main Results:
- Forty-two frameless biopsies demonstrated a 100% diagnostic yield for various intracranial lesions, including CNS lymphoma and glioblastoma.
- A 2.4% rate of asymptomatic intracerebral hematoma was observed post-frameless biopsy.
- Frame-based biopsy in 30 patients yielded 96.7% diagnostic accuracy, with no significant difference compared to frameless methods (p=0.916).
Conclusions:
- Frameless navigation-guided biopsy is equally effective and safe as frame-based stereotactic biopsy.
- The study suggests frameless biopsy can replace frame-based techniques for intracranial biopsies.
- Further research is recommended to validate these findings across a broader patient population.
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