Related Experiment Video
Updated: Jul 29, 2025
09:59
Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution
Published on: July 4, 2014
18.2K
Characterization of Pharmaceutical Tablets by X-ray Tomography.
Jaianth Vijayakumar1,2, Niloofar Moazami Goudarzi1,2, Guy Eeckhaut3
1Centre for X-ray Tomography (UGCT), Ghent University, Proeftuinstraat 86/N3, 9000 Gent, Belgium.
Pharmaceuticals (Basel, Switzerland)
|May 27, 2023
Summary
High-resolution X-ray microtomography offers advanced, non-destructive analysis of solid dosage forms like tablets. This technique is crucial for pharmaceutical development and cost-effective production, driving innovation in drug manufacturing.
Area of Science:
- Pharmaceutical Science
- Materials Science
- Imaging Technology
Background:
- Tablets are a widely used solid dosage form in drug administration due to their manufacturing simplicity and scalability.
- Non-destructive techniques are essential for characterizing internal tablet structures during drug product development and optimizing manufacturing processes.
Purpose of the Study:
- To review recent advancements in high-resolution X-ray microtomography.
- To highlight its applications in various tablet characterization methods within the pharmaceutical industry.
Main Methods:
- Review of high-resolution X-ray microtomography techniques.
- Analysis of applications in pharmaceutical tablet characterization.
- Discussion of advancements in laboratory instrumentation and synchrotron light sources.
Main Results:
- High-resolution X-ray microtomography provides valuable insights into the internal structure of tablets.
- Developments in instrumentation and data processing enhance the technique's capabilities.
- Synchrotron light sources offer high brilliance for advanced imaging.
Conclusions:
- X-ray microtomography is an indispensable tool for pharmaceutical analysis.
- The technique supports drug product development and cost-effective manufacturing.
- Continued advancements are expanding its role in the pharmaceutical industry.
Related Concept Videos
01:24X-ray Imaging
5.6K
German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
5.6K
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
158
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
158
01:10Computed Tomography
4.6K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
4.6K
01:10X-ray Diffraction of Biological Samples
3.9K
X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are scattered by the electron clouds around the sample atoms. The X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal...
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are scattered by the electron clouds around the sample atoms. The X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal...
3.9K