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Microporous/Macroporous Polycaprolactone Scaffolds for Dental Applications.

Tara Shabab1, Onur Bas1,2, Bronwin L Dargaville1,2

  • 1Faculty of Engineering, School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia.

Pharmaceutics
|May 27, 2023
PubMed
Summary
This summary is machine-generated.

This study developed advanced 3D-printed scaffolds for dental tissue regeneration. These multiphasic scaffolds offer tunable properties and enhanced cell activity, paving the way for improved regenerative therapies.

Keywords:
architecturebiomateriomicsbiomimeticdental scaffoldsdrug deliverymultiphasic

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Dental Engineering

Background:

  • Scaffold-guided tissue regeneration is crucial for dental applications.
  • Developing scaffolds with controllable properties remains a challenge.

Purpose of the Study:

  • To create multiphasic scaffolds using 3D printing and porogen leaching for dental tissue regeneration.
  • To investigate the tuneability of scaffold properties and their impact on cell behavior and drug delivery.

Main Methods:

  • Utilized melt-extrusion-based 3D printing with polycaprolactone-salt composites.
  • Employed porogen leaching to create microporosity and tune surface morphology.
  • Characterized mechanical properties, degradation kinetics, and surface roughness.
  • Assessed 3T3 fibroblast cell attachment, proliferation, and extracellular matrix production.
  • Incorporated cefazolin for drug delivery studies.

Main Results:

  • Multiscale scaffolds exhibited tuneable mechanical properties, degradation rates, and surface roughness (up to 28.75 ± 7.48 µm).
  • Enhanced fibroblast attachment, proliferation, and extracellular matrix production (1.5- to 2-fold increase) compared to single-scale scaffolds.
  • Demonstrated sustained cefazolin release from the multiphasic scaffolds.

Conclusions:

  • The developed multiphasic scaffolds offer controllable, tuneable properties for dental tissue regeneration.
  • These scaffolds promote enhanced cellular activity and can function as effective drug delivery systems.
  • The findings support the further development of these scaffolds for clinical dental applications.