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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...

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Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
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Controlled Drug Release from Nanoengineered Polysaccharides.

Ilker S Bayer1

  • 1Smart Materials, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.

Pharmaceutics
|May 27, 2023
PubMed
Summary
This summary is machine-generated.

This review highlights the importance of mathematical modeling for understanding sustained drug release from nanoengineered polysaccharides. Analyzing drug release kinetics ensures efficient development and application of these biocompatible materials.

Keywords:
controlled releasedrug releasekineticsnanofibersnanoparticlespolysaccharide

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Area of Science:

  • Biomedical Sciences
  • Nanotechnology
  • Materials Science

Background:

  • Polysaccharides are versatile biopolymers with valuable properties for drug delivery.
  • Their biocompatibility and biodegradability make them ideal for nanoscale drug encapsulation and release.
  • Nanoengineered polysaccharides offer advanced solutions in drug delivery systems.

Purpose of the Study:

  • To review sustained drug release from nanoscale polysaccharides.
  • To emphasize the critical role of drug release kinetics and mathematical modeling.
  • To guide the development and application of polysaccharide-based drug delivery systems.

Main Methods:

  • Literature review of polysaccharide applications in drug delivery.
  • Discussion of polysaccharide pharmaceutical processes (gelling, stabilization, etc.).
  • Analysis of drug release models applied to nano-polysaccharides (hydrogels, nanofibers, nanoparticles).

Main Results:

  • Sustained drug release from nano-polysaccharides involves complex mechanisms like diffusion, degradation, erosion, swelling, and interactions.
  • Mathematical modeling is crucial for predicting release behavior and optimizing experimental design.
  • Multiple models may be needed to accurately describe release profiles due to parallel mechanisms.

Conclusions:

  • Detailed kinetic analysis and modeling are essential for studies on sustained release from nano-polysaccharides.
  • Effective modeling aids in translating in vitro findings to in vivo applications.
  • Nanoengineered polysaccharides hold significant promise for future theranostic applications.