Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

158
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
158
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

903
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
903
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

348
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
348

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypoxia and IL-15 Cooperate to Induce Perforin Expression by CD8 T Cells and Promote Damage to the Skin in Murine Cutaneous Leishmaniasis.

The Journal of investigative dermatology·2025
Same author

Single-dose pharmacokinetics and lung function of nebulized niclosamide ethanolamine in sheep.

Pharmaceutical research·2023
Same author

Preparation of Nanostructured Lipid Drug Delivery Particles Using Microfluidic Mixing.

Pharmaceutical nanotechnology·2019
Same author

Novel agrochemical conjugates with self-assembling behaviour.

Journal of colloid and interface science·2017
Same author

Microfluidic preparation of drug-loaded PEGylated liposomes, and the impact of liposome size on tumour retention and penetration.

Journal of liposome research·2017
Same author

Selective Sequence for the Peptide-Triggered Phase Transition of Lyotropic Liquid-Crystalline Structures.

Langmuir : the ACS journal of surfaces and colloids·2016

Related Experiment Video

Updated: Jul 29, 2025

Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders
06:01

Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders

Published on: October 4, 2022

1.3K

Bulk Flow Optimisation of Amorphous Solid Dispersion Excipient Powders through Surface Modification.

Danni Suhaidi1, Yao-Da Dong2, Paul Wynne3

  • 1School of Engineering, Deakin University, Waurn Ponds, VIC 3216, Australia.

Pharmaceutics
|May 27, 2023
PubMed
Summary
This summary is machine-generated.

L-leucine coprocessing improves amorphous solid dispersion (ASD) powder flowability for many excipients. This study investigated L-leucine

Keywords:
L-leucineamorphous solid dispersionsbulk powder characterizationflowability enhancementparticle engineeringspray dryingsurface modification

More Related Videos

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

22.2K
Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography
06:53

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography

Published on: January 25, 2019

14.4K

Related Experiment Videos

Last Updated: Jul 29, 2025

Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders
06:01

Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders

Published on: October 4, 2022

1.3K
Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

22.2K
Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography
06:53

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography

Published on: January 25, 2019

14.4K

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Chemical Engineering

Background:

  • Amorphous solid dispersions (ASDs) enhance drug oral bioavailability and macromolecule stability in solid dosage forms.
  • Spray-dried ASDs exhibit surface cohesion and hygroscopicity, negatively impacting powder flow and processing.
  • Surface modification is crucial for improving the bulk properties of ASDs.

Purpose of the Study:

  • To investigate the effectiveness of L-leucine (L-leu) coprocessing in modifying the particle surface of ASD-forming materials.
  • To assess the impact of L-leu on the bulk characteristics and flowability of various prototype ASD excipients.
  • To understand the mechanistic behavior of L-leu during coformulation with different polymers.

Main Methods:

  • Coprocessing of L-leucine with various prototype ASD excipients including maltodextrin, polyvinylpyrrolidone (PVP K10 and K90), trehalose, gum arabic, and hydroxypropyl methylcellulose (HPMC E5LV and K100M).
  • Spray-drying under controlled conditions to minimize particle size influence on cohesion.
  • Morphological evaluation using scanning electron microscopy (SEM).
  • Bulk powder characterization using a powder rheometer to assess flowability, flow rate sensitivity, and compactability.

Main Results:

  • L-leucine coprocessing generally improved the flowability of maltodextrin, PVP K10, trehalose, and gum arabic formulations.
  • Scanning electron microscopy revealed both known and novel morphological changes on the particle surfaces.
  • Polyvinylpyrrolidone K90 and hydroxypropyl methylcellulose formulations presented unique challenges, offering insights into L-leucine's mechanistic behavior.

Conclusions:

  • L-leucine is an effective excipient for improving the powder flow properties of certain amorphous solid dispersions.
  • Further research is recommended to explore the interplay between L-leucine and the physico-chemical properties of coformulated excipients.
  • Enhanced bulk characterization tools are needed to fully understand the multifactorial impact of L-leucine surface modification.