Related Experiment Video
Updated: Jul 29, 2025
06:15
Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
12.0K
Deep Eutectic Solvents for Efficient Drug Solvation: Optimizing Composition and Ratio for Solubility of
Ilan Shumilin1,2,3, Ahmad Tanbuz1,2,3, Daniel Harries1,2,3
1Institute of Chemistry, The Hebrew University, Jerusalem 9190401, Israel.
Pharmaceutics
|May 27, 2023
Summary
Adding water to deep eutectic solvents (DES) like urea and choline chloride (CC) enhances beta-cyclodextrin (β-CD) solubility. Optimal DES compositions shift from the eutectic ratio, improving drug formulation potential.
Area of Science:
- Pharmaceutical Science
- Physical Chemistry
Background:
- Deep eutectic solvents (DES) are promising pharmaceutical solubilizers.
- Dissecting component contributions to solvation in complex DES mixtures is challenging.
- Phase separation limits component ratio variation in DES.
Purpose of the Study:
- To investigate the effect of water addition on beta-cyclodextrin (β-CD) solubility in urea-choline chloride (CC) DES.
- To determine optimal DES compositions for enhanced β-CD solvation.
- To develop a methodology for linking DES component interactions to solute solubility.
Main Methods:
- Solubility measurements of β-CD in urea-CC DES with varying water content and component ratios.
- Analysis of DES phase behavior and stability.
- Development of a methodology to study preferential solvation.
Main Results:
- Water addition stabilizes the DES single-phase region and enhances β-CD solubility.
- Optimal β-CD solubility is often achieved at non-eutectic DES compositions.
- β-CD solubility can be enhanced by a factor of 1.5 at specific hydration levels and urea:CC ratios.
Conclusions:
- Water addition is a viable strategy to improve DES performance as solubilizers.
- Rational drug and excipient formulation requires understanding solute-DES component interactions.
- The presented methodology enables dissection of interactions for improved formulation development.
More Related Videos
Related Concept Videos
01:27Factors Influencing Drug Absorption: Drug Dissolution
598
The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
598
01:20Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
238
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
238
01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
903
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
903
01:21Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH
1.6K
Drug absorption within the gastrointestinal (GI) tract is a complex process influenced by several critical factors, including the site pH, the drug's dissociation constant (pKa), and the drug's lipophilicity. The GI tract exhibits a pH gradient, with an acidic environment in the stomach and a more alkaline environment in the small intestine. This pH variation directly affects the ionization state of drugs.
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
1.6K
02:16Solution Formation
32.0K
There is no one solvent that can dissolve every type of solute. Some substances that readily dissolve in a certain solvent might be insoluble in a different solvent. A simple way to predict which substances dissolve in which solvent is the phrase "like dissolves like". This means that polar substances, such as salt and sugar, dissolve in a polar substance like water. In contrast, non-polar substances are more soluble in non-polar solvents such as carbon tetrachloride.
This selective...
This selective...
32.0K
01:15Optimizing Chromatographic Separations
442
Optimizing chromatographic separations is crucial for obtaining clean separations in a minimum amount of time. Optimization is required for several factors, including kinetic effects related to band broadening, plate height, capacity factor, and separation factor.
Band broadening refers to spreading solute bands as they travel through the column. This broadening can impact resolution. Plate height (H) represents the length required for one theoretical plate. A lower plate height corresponds to...
Band broadening refers to spreading solute bands as they travel through the column. This broadening can impact resolution. Plate height (H) represents the length required for one theoretical plate. A lower plate height corresponds to...
442