Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

14
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
14
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

41
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
41
Urinary Tract Calculi VI: Surgical Management01:25

Urinary Tract Calculi VI: Surgical Management

11
Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
11

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Betrixaban for Deep Venous Thrombosis Prevention in a Patient with End-Stage Renal Disease on Intermittent Hemodialysis.

Journal of biosciences and medicines·2026
Same author

Evaluation of Pirfenidone for the Treatment of Acute Respiratory Distress Syndrome: A Case Report.

Journal of biosciences and medicines·2026
Same author

Proposed Development of a New Staging System for Hearing Loss: Countermeasure 2 of the Hearing Health Collaborative.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2025
Same author

Geographic Variations of Intensive Care Unit Admissions with Substance-Related Diagnoses in the United States.

Journal of intensive care medicine·2025
Same author

Evaluation of Rivaroxaban Exposure via Anti-Xa Levels During VTE Prophylaxis in Hospitalized Patients.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2025
Same author

Techniques in Management of Cholesteatoma: Subtotal Petrosectomy; Blind Sac Closure.

Otolaryngologic clinics of North America·2024
Same journal

Laryngeal Injuries Following General Endotracheal Anesthesia: A Case Series.

The Annals of otology, rhinology, and laryngology·2026
Same journal

Clinical and Voice Outcome Differences in Vocal Cord Cysts with and Without Sulcus Vocalis: Insights From a Tertiary Center in Saudi Arabia.

The Annals of otology, rhinology, and laryngology·2026
Same journal

Bioabsorbable Stenting in a Case of Severe Pediatric Posterior Glottic Stenosis.

The Annals of otology, rhinology, and laryngology·2026
Same journal

Efficacy and Safety of Finafloxacin Otic Suspension, 0.3% for the Treatment of Acute Otitis Externa: Results from two Phase III Randomized Clinical Studies.

The Annals of otology, rhinology, and laryngology·2026
Same journal

Evaluation Of the Expression Levels Of SerpinB3/B4/B10, Interleukin-17 As Biomarkers For Chronic Rhinosinusitis With Nasal Polyps.

The Annals of otology, rhinology, and laryngology·2026
Same journal

Correlation of Patient-Reported Symptoms With Rhinogram Features Beyond Simple Airway Resistance.

The Annals of otology, rhinology, and laryngology·2026
See all related articles

Related Experiment Video

Updated: Jul 29, 2025

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
12:21

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration

Published on: November 26, 2015

17.5K

Debilitating Gentamicin Ototoxicity: Case Report and Recommendations Against Routine Use in Surgical Prophylaxis.

Olivia A Kalmanson1, Kaitlin C McLoughlin2, Tyree H Kiser3

  • 1Department of Otolaryngology, University of Colorado School of Medicine, Aurora, CO, USA.

The Annals of Otology, Rhinology, and Laryngology
|May 27, 2023
PubMed
Summary
This summary is machine-generated.

Gentamicin can cause severe, permanent ototoxicity, even in patients with penicillin allergies. Alternative antibiotics should be considered to minimize risks, especially for those with pre-existing vestibular conditions.

Keywords:
allergy delabelingaminoglycosidecolorectal surgerygentamicinototoxicityperioperative antibioticsurgeryvestibular toxicity

More Related Videos

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
09:52

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Published on: March 16, 2018

9.5K
Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice
09:06

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice

Published on: January 9, 2019

14.0K

Related Experiment Videos

Last Updated: Jul 29, 2025

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
12:21

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration

Published on: November 26, 2015

17.5K
Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
09:52

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Published on: March 16, 2018

9.5K
Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice
09:06

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice

Published on: January 9, 2019

14.0K

Area of Science:

  • Ototoxicity
  • Antibiotic Stewardship
  • Vestibular Dysfunction

Background:

  • Aminoglycoside antibiotics like gentamicin are effective against Gram-negative and Gram-positive bacteria.
  • Gentamicin carries significant risks, including nephrotoxicity and ototoxicity, which can lead to permanent vestibular dysfunction.
  • Ototoxicity from gentamicin can occur even after a single dose.

Observation:

  • A patient with Meniere's Disease received gentamicin for surgical prophylaxis due to a penicillin allergy.
  • The patient experienced severe ototoxicity, impacting her ability to work and drive.
  • Vestibular testing confirmed high-grade bilateral vestibular loss, significantly worse than previous assessments.

Findings:

  • Gentamicin is indicated for surgical prophylaxis in penicillin-allergic patients when cephalosporins are contraindicated.
  • True penicillin allergies include IgE-mediated reactions or severe exfoliative conditions.
  • This case highlights the severe ototoxic risk of gentamicin, particularly in susceptible individuals.

Implications:

  • Prudent use of gentamicin is recommended, especially in patients at risk for otologic damage.
  • Alternative antibiotic agents should be prioritized over gentamicin when possible.
  • Healthcare providers should carefully weigh the risks and benefits of gentamicin, considering patient history and alternative options.