Related Experiment Video
Updated: Jun 12, 2026

Using a Split-belt Treadmill to Evaluate Generalization of Human Locomotor Adaptation
Published on: August 23, 2017
Fatigue-related gait adaptations in children with cerebral palsy
Laura M Oudenhoven1,2, Marjolein M Van Der Krogt1,2, Sanne Ettema3,4
1Rehabilitation Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Insights
Prolonged walking worsens gait in children with cerebral palsy (CP), affecting knee and ankle movements. Fatigue impacts gait kinematics but not energy cost, suggesting personalized interventions for CP patients.
Area of Science:
- Biomechanical analysis of human movement.
- Pediatric rehabilitation and motor control.
Background:
- Children with cerebral palsy (CP) often exhibit altered gait patterns.
- Understanding the impact of fatigue on gait is crucial for rehabilitation.
Purpose of the Study:
- To investigate the effects of prolonged walking-induced fatigue on gait kinematics, kinetics, and energy cost of walking (ECoW) in children with CP.
Main Methods:
- A prospective observational study involving children with CP and typically developing children.
- A prolonged, intensity-based walking protocol on an instrumented treadmill with gas analysis.
- Gait parameters, kinetics, and ECoW were assessed before and after a 6-minute walk and moderate-intensity walking exercise.
Main Results:
- Gait Profile Scores worsened in both groups with prolonged walking.
- Children with CP showed increased knee flexion and ankle dorsiflexion during specific gait phases.
- No significant changes in gait kinetics or energy cost of walking were observed in either group.
Conclusions:
- Kinematic deviations in children with CP progress with prolonged walking.
- Significant individual variability in gait adaptations to fatigue was observed.
- An individualized approach is recommended for assessing fatigue effects on gait in clinical practice for children with CP.
Aim:
To obtain insights into the effects of fatigue on the kinematics, kinetics, and energy cost of walking (ECoW) in children with cerebral palsy (CP).
Method:
In this prospective observational study, 12 children with CP (mean age 12 years 9 months, SD 2 years 7 months; four females, eight males) and 15 typically developing children (mean age 10 years 8 months, SD 2 years 4 months; seven females, eight males) followed a prolonged intensity-based walking protocol on an instrumented treadmill, combined with gas analysis measurements. The protocol consisted of consecutive stages, including a 6-minute walking exercise (6MW) at comfortable speed, 2 minutes of moderate-intensity walking (MIW) (with a heart rate > 70% of its predicted maximal), and 4 minutes walking after MIW. If necessary, the speed and slope were incremented to reach MIW. Outcomes were evaluated at the beginning and end of the 6MW and after MIW.
Results:
With prolonged walking, Gait Profile Scores deteriorated slightly for both groups (p < 0.01). Knee flexion increased during early stance (p = 0.004) and ankle dorsiflexion increased during late stance (p = 0.034) in children with CP only. Negligible effects were found for kinetics. No demonstrable change in ECoW was found in either group (p = 0.195).
Interpretation:
Kinematic deviations in children with CP are progressive with prolonged walking. The large variation in adaptations indicates that an individual approach is recommended to investigate the effects of physical fatigue on gait in clinical practice.
More Related Videos
Related Concept Videos
Classification of Illness
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe and...
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Information Processing Approach
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
Learning Disabilities
Dyslexia
Dyslexia is a...
Alterations in Muscle Tone ll

